ID A0A3M0JSW7_HIRRU Unreviewed; 525 AA.
AC A0A3M0JSW7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=DUI87_21011 {ECO:0000313|EMBL:RMC01850.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC01850.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC01850.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC01850.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC01850.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993,
CC ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC01850.1}.
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DR EMBL; QRBI01000134; RMC01850.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0JSW7; -.
DR STRING; 333673.A0A3M0JSW7; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 2.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 155..350
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 371..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 473..518
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 525 AA; 57588 MW; BFA49B7AE4EF2F63 CRC64;
MAPPTPLLAV RGSEGLYMVN GPPSFTESTA FQRDSGKNCK AVAFSKDGSL FAWCNGEKVN
VVNVTRAELL HSFDLPKTVC LEFSPKNNVL ATWQAYANTI ANKLHLQKVS DFVLSPGAQP
TKVAVYVPGS KGAPSFVRLY QYPNFGGPQS ALANKSFFKA DKVTMLWNKK ATAVLVVAST
EVDKSGASYY GEQTLHYVGA SGESAVVQLP KNGPIYDVAW SPNSVEFCAV YGFMPAKATV
FNLKCDPVFD FGTGPRNAAY YSPHGHILVL AGFGNLRGQM EVWDVKNYKL ISKPVASDST
FFAWCPDGEH IVTATCAPRL RVSNGYKIWH YTGSVLHSYE VPSDEEMWQV FWQPFLDGVF
PERAVKYQAV PSDLPGAEPR PAQAYRPPAL RNKPVTTSKL HEDEPPQNMK PQLGGSDKPF
SKTALKNQRK HEAKKAAKQE AKADAHQGPA QVKTPQNALQ NTVPAMTTGD PEVDKKIKNL
KKKLKAIEQL KEQAAAGKQL EKNQVEKIQK EAALLKELED LELGV
//
