ID A0A3M0JV73_HIRRU Unreviewed; 1328 AA.
AC A0A3M0JV73;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:RMC04808.1};
GN ORFNames=DUI87_17980 {ECO:0000313|EMBL:RMC04808.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC04808.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC04808.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC04808.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC04808.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC04808.1}.
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DR EMBL; QRBI01000123; RMC04808.1; -; Genomic_DNA.
DR STRING; 333673.A0A3M0JV73; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd05482; HIV_retropepsin_like; 1.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 1.10.1200.30; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 1.10.375.10; Human Immunodeficiency Virus Type 1 Capsid Protein; 1.
DR Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR InterPro; IPR001037; Integrase_C_retrovir.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR034170; Retropepsin-like_cat_dom.
DR InterPro; IPR018061; Retropepsins.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR008919; Retrov_capsid_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR010661; RVT_thumb.
DR PANTHER; PTHR41694:SF4; ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED; 1.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR Pfam; PF00607; Gag_p24; 1.
DR Pfam; PF00552; IN_DBD_C; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00077; RVP; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF06817; RVT_thumb; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF47943; Retrovirus capsid protein, N-terminal core domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS51027; INTEGRASE_DBD; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00450};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00450}.
FT DOMAIN 330..405
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 466..655
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 888..1025
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 1030..1071
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 1080..1242
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1252..1299
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS51027"
FT DNA_BIND 1252..1299
FT /note="Integrase-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT REGION 1302..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1328 AA; 149200 MW; F8FB072EEC43CD4F CRC64;
MHQPSPVPSV SPVVYKGSRR RQRVRAIHHP FPQSTIRDLC KAHRDYGRDS PYFRGLLRSD
LDAAVVIPAD LKQLFSCLLD STEFKLWVAA WRQQLREALP SLLRDPETAV DDNGNPLTLE
HLMGEGRWAD PSDQTSDIPI KALQIAREHA VSAFFGMVPD GPVVPYYKIM QGAKESFTKF
VERLTRAIEV QVTEVAPILV TSSRHEPYRL RLTEALHLRT ADWTFLSINT KEQGAWPVQG
KELVIIGDCK YTPQEVEILP GVLVNNPRDL VLWLRCTHPP TFIPKGQVIA QIIPTRGPNN
TPVACPVQAI TEERPRVDCE FRVGGETINI TGLLDTGADV TVVPAQDWPS HWALQDVAGH
VQGVGGLQLA RQSRSIVQIK GPKGQLANIR PFVLDYKEPL LGRDLMSQWG VKIDIPDPSV
EISAASIDER PTKKLNWLTN KPVWVEQWPL SKPKLKALEE LVKEQLAKGH IVETDSPWNS
PVFVIQKPGK DKWRLLQDLR QINNVIEDMG SLQPGMPSPT MLPQNWQLAV IDIKDCFFQI
PLHPDDAPRF AFSVPTINRE APRRRYHWRV LPQGMKNSPV ICQWYVASLL SPVRAAAGQA
IIYHYMDDVL VCAPNDDMLS HVLGLTVDAL VAAGFELQEE KVQRMPPWKY LGLEIGRRTI
VPQKLAIRTK VSSLADVHQL CGSLNWVRPW LGLTTNDLAP LFNLLKGGEE LSSPRVLTPE
AEKALEKVQD AMSKRQAHRI DPELPFKFII MGKLPHLHGM IFQWKSIPKK DREGNDPLLI
IEWVFLSHHR SKRMTRPQEL VAELIRKARF RIRELAGCDF ECIHIPIGLR SGQISKAMLE
HLLQENEALQ FALDSFTGQI SIHRPAHKIF NSETKFILSL KEVRSRRPLK ALTVFTDASG
RSHKSVLTWK DPQTQQWEAD IAEVEGSPQV AELAAVVRAF ERFPEPFNLV TDSAYVAGVV
SRADQAILQE VSNIALYDLL SKLVRLVSHR EQPYFVMHTR SHTDLPGFIA EGNRKADALA
APAEMAPLPN IFMQAKLSHQ LFHQNAPGLV RRFHLTREQA RAIVAACPSC SQQAVPTLHA
GVNPRGLRSC EVWQTDVTHF PQFGRQKYIH VSVDTFSGAV FASAHTGEKA GDAIKHLIHA
FSFMGIPREL KTDNGPAYKS RELRSFLQQW GVEHKTGIPH SPTGQAMVER THGTIKRVLH
QQQRVLKTES PSVRLARALF TINFLNCSYE GLNPPIVRHF GASSLFGVKE RPQVMVRDPG
SGGTEGPHDL VTWGRGYACV STPTGPKWIP AKWVRPYVPK SPGSGKINSP QVTVAAWRRK
RKTSNEES
//
