ID A0A3M0JW22_HIRRU Unreviewed; 911 AA.
AC A0A3M0JW22;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:RMC04945.1};
GN ORFNames=DUI87_18122 {ECO:0000313|EMBL:RMC04945.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC04945.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC04945.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC04945.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC04945.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC04945.1}.
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DR EMBL; QRBI01000123; RMC04945.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0JW22; -.
DR STRING; 333673.A0A3M0JW22; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF5; INTEGRIN ALPHA-8; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 3.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 31..911
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5017852071"
FT REPEAT 35..97
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 111..172
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 301..366
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 367..425
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 541..697
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 699..839
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 845..887
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 476..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 911 AA; 101704 MW; BF3136F32F86C6A6 CRC64;
MLPLSRGRPR RWQHPLLLLS ALLWAPALVA FNLDEEKLTV YSGPPGSYFG YSVDFYIPDP
STVSVLVGAP KANTTQPDIV EGGAVYYCAW PATRCRQIPF DNTNNRKIKV NGTREPIEFK
TNQWFGATVK AHKEKVVACA PLYHWRTLKD SPEKDPVGTC YVAIQNFSAY AEYSPCRNSQ
VITASIADII ANYSFKDILR KLAREKQTGV APPSYDDNYM GYSVAAGEFT GDSEQGLSDT
DPKGFDIHGS FKWCGIHVAC TTQIAKPVYC WSFILSELVA GVPRGAQNFG YVSIINSSDL
TFIQNFTGEQ MASYFGYTVA VSDVNNDGLD DILVGAPLFM EREFESKPKE VGQVYLYLQE
SAFLFQDAQI LTGAEVFGRF GSAITHLGDL NQDGYNDIAI GAPFAGEDRR GKVLIYNGYS
NGLNPNPSQV LNGAWASQSM PSGFGFTLRG DSDVDKNDYP VVPLIQALRI KNKHGLEQKT
NDMSGNDKQK KTPPNTKLTK NPSNTSKIKI NKIENLLWGY YGYHYLIVGA FGAGKAVVYR
ARPVVTVNAY LILNPMIVNP DNKTCQLPSS QLLVACFTVR VCTEFEGQSI SDEIVLKGEL
QLDSLKQKGA VRRTLFFDYH QSHHYFSIVI ERQKQLHCQD FLVYLRDETE FRDKLSPINI
NFNYSLDESS FEDSLTVKPI LNYYQKNSLA EQAYILVDCG EDNLCIPDLQ LSAVPDTDQL
IIGEENCVML IINPRNDGEG AYEAELHIKI PPEADYTGVE RNNKALRVLS CDYKMENETR
MVVCDLGNPM VAGANFSTGI RFSVQHFENA DFSISFELQI KSSNKINPTS NLVNLHINIS
AVAQVQIRGV SHPPTIILPL HNWEPKDQPT KEEEVGPLVE HIYEVKIMYV ATGPQAAPTE
LLMILVYFLY Q
//
