ID A0A3M0K2A0_HIRRU Unreviewed; 1027 AA.
AC A0A3M0K2A0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=DUI87_15896 {ECO:0000313|EMBL:RMC06461.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC06461.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC06461.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC06461.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC06461.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC06461.1}.
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DR EMBL; QRBI01000120; RMC06461.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0K2A0; -.
DR STRING; 333673.A0A3M0K2A0; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 818..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 867..1011
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1027 AA; 117729 MW; 695273BBC7626CC3 CRC64;
MLLSGAWFPK TLPCDVSSSE GTVTVDCTDR RLTEVPRGIP GNATNLTLSI NHIPHIYPTS
FNRLENLQEI DFRCNCVPVK LGPKNHVCNS PLKIENGSFA ALTGLKSLYL DANQLAEIPR
GLPATLTLLS LEANNIFSIQ KANFSELGNI EVLYLGQNCY YQNPCNVSFE IERTAFLGLK
KLTILSLKSN NLTQIPPNLS STLKELYIYN NMIQEVQEQD LSGLHNLEIL DLSGNCPRCY
NAPYPCIPCP KSSVQIHPKA FDSLQNLKIL RLHSNSLQSI PSSWFKNIKN LKELDLSQNF
LMREIGDAQF LTLIPSLVQL DLSFNFELKV YSPFLNLSET FSSLSNLETL RLKGYVFKEL
RAQDLHPLLS LSNLTVLDLG TNFIKVADLK VFEKFPALKF IDLSVNKISP SSGESNFYGF
CSNPGISVEQ YNRQVQQEMH YFRYDVYERS CRSKDKEASS YESLVKEDCL NYGKTLDLSR
NNIFFVNPSD FQGLSYLKCL NLSDNAISQT LNGSEFSYMS GLKYLDFSNN RVDLLYQTAF
KELKLLEILD LSNNQHYFLA EGVTHVLDFM KNLAHLRKLM MNWNEISTTT DTGMESQSLR
ILEFRGNRLD ALWKDGNDRY LSFFKNLTSL EELDISFNSL SFLPHSVFEK MPPSLKILNL
TNNQLKSFIW GNLPSLKNLV TLDLSNNLLS TVPRELSNCT SSLQELMLRN NRIQQLTKYF
LRGAFELRYL DLSLNKIEII KRSSFPENVI NNLKMLLLHG NPFKCNCEAV WFVWWINRTQ
VTIPLLATDV TCAGPGAHKG KSMVFLDLYT CELDTSYLIL YALSASAVLG LMVFTVMSHL
YFWDVWYSYH YCTAKLKGYR RLSSPAACYD AFIAYDSEDP AVNEWVLQEL VERLENQKAR
QFNLCLEGRD WLPGQPVFDN LSQSIQLSKK TIFVLTHRYI RSGRFKTTFY MAHQRLLDEK
MDVIILIFLE KVLQKSRYVR LRKRLCRSSV LEWPTNPQSQ PYFWQCLKNA IATSNSLAYN
KLLQETV
//
