ID A0A3M0K543_HIRRU Unreviewed; 2493 AA.
AC A0A3M0K543;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Notch receptor 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_14553 {ECO:0000313|EMBL:RMC08312.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC08312.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC08312.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC08312.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC08312.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC08312.1}.
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DR EMBL; QRBI01000117; RMC08312.1; -; Genomic_DNA.
DR STRING; 333673.A0A3M0K543; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0071228; P:cellular response to tumor cell; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 27.
DR CDD; cd21703; JMTM_Notch2; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 34.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022336; Notch_2.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 20.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF12661; hEGF; 7.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01985; NOTCH2.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 36.
DR SMART; SM00179; EGF_CA; 32.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 14.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF90193; Notch domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 20.
DR PROSITE; PS00022; EGF_1; 33.
DR PROSITE; PS01186; EGF_2; 26.
DR PROSITE; PS50026; EGF_3; 35.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..2493
FT /note="Notch receptor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018278797"
FT TRANSMEM 1716..1738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..66
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 67..105
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 108..146
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 147..183
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 185..222
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 224..261
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 263..299
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 363..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 403..439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 440..478
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 480..519
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 521..557
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 559..595
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 597..633
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 635..670
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 672..708
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 710..745
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 747..783
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 785..820
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 822..858
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 860..898
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 900..936
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 938..974
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 976..1012
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1014..1050
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1052..1088
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1090..1126
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1139..1174
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1176..1212
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1214..1250
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1252..1292
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1294..1332
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1334..1373
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1376..1412
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1413..1451
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1450..1503
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1504..1540
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1541..1582
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1914..1946
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1981..2013
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2014..2046
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2047..2079
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1786..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2139..2216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2253..2273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2407..2493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2172..2186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2193..2216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2407..2429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2445..2493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 501
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 504
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 521
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 524
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 538
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 562
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 576
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 577
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 56..65
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 76..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 95..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 136..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 173..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 212..221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 251..260
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 391..400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 429..438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 449..466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 468..477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 484..498
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 492..507
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 509..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 525..536
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 530..545
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 547..556
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 563..574
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 568..583
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 585..594
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 623..632
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 639..649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 660..669
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 698..707
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 714..724
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 735..744
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 773..782
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 789..799
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 810..819
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 848..857
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 869..886
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 888..897
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 926..935
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 964..973
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1002..1011
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1040..1049
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1078..1087
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1116..1125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1164..1173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1202..1211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1240..1249
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1282..1291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1303..1320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1322..1331
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1363..1372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1402..1411
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1422..1439
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1441..1450
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2493 AA; 267934 MW; 1FCF23EF98DE163B CRC64;
MARGAGPALA ALLALVLAVL RRAEPAAALQ CMDDSKPCVN EGKCIPYQNG TGYCKCREGF
LGDYCQYRNP CESNTCKNGG TCEAASLIGK PTCKCAPGFT GEECQYSESH LCYVSQPCLN
GGTCHPHGQD TYECVCLPGF TGKECQWIDA CTSQPCANGS TCTVSGNKFS CTCLAGYTGQ
KCEIDVNECA TPGLCQHGGT CVNLPGSYRC QCKPGYTGHR CESVYVPCSP SPCMNGGTCH
QTSDFTFECN CLPGFEGSVC GHNVDDCPNH KCLNGGVCVD GVNTYNCRCP PQWTGMLVVF
AWFDDCAVEV VAFERAGIKG QQSGDRSVHF GHVVCARTSS SLSIRRANKP PCFCAPGQFC
TEDVDECQLQ PNACQNGGTC TNHNGGYACV CVNGWSGDDC SKNIDDCFTA SCANGSTCID
RVASFSCICP EGKAGLLCHL DDACVSNPCQ KGALCDTNPV NGNYICTCPQ GHKGADCTED
VDECAMANSN PCEHAGKCVN TEGSFHCECL KGYTGPRCEM DINECHSNPC QNDATCLDKI
GGFTCLCMPG FKGVHCEEDI DECLSNPCVN NGVCLDKVNR FLCVCPPGFS GAVCQIDIDD
CSSTPCLNGA KCIDHPNGYE CQCATGFTGL LCEENINNCD PDPCHYGECQ DGIDSYTCVC
NPGYMGAICS EQIDECHSNP CLHQGRCIDL VNGYQCNCLL GTSGVNCENN FDDCASNPCI
HGDCIDGINR YNCACKPGFT GPRCNADIDE CTSSPCHNGG TCINEVNGFR CVCPEGFHHP
HCQAQADGCL SNPCVHGNCT HIPTGYKCVC DPGWTGDYCS TEGNECKSNP CQNGGTCEDL
LNGYKCTCRK GFKGVNCQVV VSPCSPNPCE NSGICQESPD SEGYTCQCAP GWEGERCTVD
IDECLSKPCK NHALCHNIQG SYLCECRPGF TGGDCDSNID DCLSNPCQNG ASCVDGINSF
SCICLPGFHG DKCQTDTNEC LSEPCRNGGT CTHYVNSYTC KCPPGFEGTN CENNIDECTE
SSCFNGGTCV DGINSFTCQC PLGFTGPFCL TEINECDSHP CLNRGTCVDS LGTYRCICPL
GYTGKNCKSL VDLCSKSPCK NKGTCVQTLA QTRCVCPPSW TGAYCDVPNV SCQVAASQRG
VPVDQLCQHS GHCLNVGNTH HCQCQVGYTG SYCEVQLDEC DSSPCQNGAT CRDHLGGYQC
ECVAGYQGVN CEYEVNECQF QPCQNGGTCI DLVNHFKCSC PPGTRGRFCE ENVDDCISAS
GVPRCFNGGQ CIDQIGGYSC LCPQGFAGER CEGDINECLS NPCNPRGSLD CVQLTNDYRC
ICRSAFTGRH CESVIDVCPR KPCQNGGTCA VASNMPDGFI CQCPPGYSGA KCEFSSHSTC
GQVKCKKGEQ CIQTSSGPRC YCPKLSVGEE CQTNPGCASA PCQNGGSCHP HSQPPYYYCQ
CPVHTQGSHC EQPVTLSPEP RGCLDSQCAE KARDGYCDED CNTHACQWDG GDCSLRMEDP
WANCSSSLRC WMLFNGQCDE FCNTPECLFD NFECQQNSRT CKYDKYCADH YADGRCDQGC
NSEECGWDGL DCAGDKAEKL AEGTLIIVVL MPPDELLGDV RSFLRTLGTL LHTNLRIKLD
SQGNPMVFPY YGEKSAARSR RSLVVVRKHR ELEQEVIGTK VFLEIDNRQC AEDSEQCFHN
TEAAAALLAA QAIKGMLPYP FVSVQSEPLL PPKTQLLYLL AVAALIILLI LLLGVMMAKR
KRKHGSLWLP EGFILRRDPS NHKRREPVGE DAVGLKNLSV QIPEGNLADP GTTEHWAGDG
GPQPKRAKAE DQALLPEGDE QIDQRQWTQQ HLEAADVCGS TSLALTPPQA DQEVDVLDVN
VRGPDGCTPL MLASLRAGGS DISEDDEDGE DSSANIITDL IYQGANLQAQ TDRTGEMALH
LAARYSRADA AKRLLDAGAD ANARDNMGRT PLHAAVAADA QGVFQILIRN RVTDLDARMN
DGTTPLILAA RLAVEGMVAE LINCQADVNA VDDHGKSALH WAAAVNNVEA TLVLLKNGAN
RDMQDNKEET PLFLAAREGS FEAAKILLDH FANRDITDHM DRLPRDVAQD RMHHDIVQLL
NEYNVAHSPA GHPGAMLNSA LSPVICGPNR SFLNLKHASL SKKSRKPNAK GMPASLTKDA
KRRRKKSLSE GKGQFSESSV TLSPVDSLES PHAFASEPTS SPVMPSPGVL HSSPSSLLTA
PSVQAAHTMS FSNLHEMQPL GRGSSTVLPS VSQLLSQHRT TPPNSGLGRL RPGSVSTEWM
NRMEVNESQY NEMFGMVPQV MHSHPGVSQQ GGLVQADAKH LGVSRESLPP IMTFQLVPKG
SINQQALPQQ AQSNCAQNVA GPLSSMYQIP DLAQLPSASF SMAAIPQQDG QVAQTVLPAY
HQFQSSMGKY PTPPSQHSCY SSATERTPSH NRHLQGEHPY LTPSPESPDQ WSSSSPHSAS
DWSDVATSPG NNQRGPAAAH MTEQQRNNMQ VYA
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