ID A0A3M0K587_HIRRU Unreviewed; 1084 AA.
AC A0A3M0K587;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=DUI87_14489 {ECO:0000313|EMBL:RMC08248.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC08248.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC08248.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC08248.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC08248.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC08248.1}.
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DR EMBL; QRBI01000117; RMC08248.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0K587; -.
DR STRING; 333673.A0A3M0K587; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF5; VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 512..547
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 766..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1084 AA; 123472 MW; 27A6BF2CA343E5CD CRC64;
MPQAFIQALF LSKTGAKTNK GRDIKTIKSL RVLRVLRPLK TIKRLPKLKA VFDCVVTSLK
NVFNILIVYK LFMFIFAVIA VQLFKGKFFY CTDSSKDTQK DCIGNYVDHE KNKMEVKCRE
WKRHEFHYDN IIWALLTLFT VSTGEGWPQV LQHSVDVTEE DRGPSRSNRM EMSIFYVVYF
VVFPFFFVNI FVALIIITFQ EQGDKMMEEC SLEKNERACI DFAISAKPLT RYMPQNRHTF
QYRVWHFVVS PSFEYTIMAM IALNTVVLMM KYYSAPYTYE LALKYLNIAF TMVFSLECVL
KIIAFGFLNY FRDTWNIFDF ITVIGSITEI ILTDTKLVNT SSFNMSFLKL FRAARLIKLL
RQGYTIRILL WTFVQSFKAL PYVCLLIAML FFIYAIIGMQ VFGNIKLDEE SHINRHNNFR
SFLGSLMLLF RSATGEAWQE IMLSCLEGKG CEPDTTATSG QNENERCGTD LAYVYFVSFI
FFCSFLMLNL FVAVIMDNFE YLTRDSSILG PHHLDEFVRI WAEYDRAACG RISYKDMYKL
VRVISPPLGL GENCPYRVAC KRLVLMNMPV AEDMTVHFTS TLMALIRTAL DIKIAKGGAD
WQQLDSELQK EILTIWPHLS QKMLDLLVPM PKTSDLTVGK IYAAMMIMDY YKQSKAKKQR
QQLEEQKNAP MFQRMEPSSL PQEIISNAKA LPYLQQDTLS GLSSRGGFPS LSPLSPQEIF
QLACMDPAQE QFQEHQSLEP EVREFQRVQP SNRGSYLPVD TQDHAVSGRA SSMPRLTVDP
QVVTDTSSMR RSFSTIRDKR PNSSWLDEFS MERSSDNTYK SRRRSYHSSL QLSARRLNAD
SGHRSEGHRS GRERGRSKER KHLLSPDISR CNSEERSPQA QEESPERRRE SRSPSEGRSQ
TPSRQGVGSL SESSIPSVSD TSTPRRGRRQ LPPVPPKPRP LLSYASMLRH AGDASPPADE
SEGGSPLLSS ALDPNAAGPA ESSSSPAGRQ SRQSTPQRYI SEPYLALHDD SHASDCGEEE
TLTFEAAVAT SLGRSNTIGS APPLRHGWQM PNGHYRRRRR GAAQGVVCGA SIDVLSDTEE
DDKC
//
