ID A0A3M0K5S2_HIRRU Unreviewed; 879 AA.
AC A0A3M0K5S2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:RMC08526.1};
GN ORFNames=DUI87_14772 {ECO:0000313|EMBL:RMC08526.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC08526.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC08526.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC08526.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC08526.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC08526.1}.
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DR EMBL; QRBI01000117; RMC08526.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0K5S2; -.
DR STRING; 333673.A0A3M0K5S2; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF5; MUCOLIPIN-3; 1.
DR Pfam; PF21381; MCLN_ECD; 3.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 852..874
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..183
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 284..421
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT DOMAIN 515..565
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 586..675
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
SQ SEQUENCE 879 AA; 102183 MW; 6CFBE1710BDEAB09 CRC64;
MVVAFKEENT VAFKHLFLKG YMDRMDDTYA VYTQRDVYDQ IFFAINQYLQ LPNISVGNHA
YEKRGAEETP LAVCQQFYKR GIICPGNDTF DIDPEIVTGD EPNLFYQFFG RTGPTFLINS
LKTLQLVAVQ LMFNLKAINL QTVRHHELPD CYDFTLRIVF DNKAHSGRIK ISLDNDIAIR
ECKDWHVSGS IQKNTHYMMI FDAFVILTCL ASLILCTRSV IKGIWLQREF VSFFLYYYKK
EVSFSDQMEF VNGWYILIMV SDVLTIVGST LKMEIQAKSL TSYDVCSILL GISTMLVWLG
VIRYLGFFQK YNLLILTLRA ALPNVMRFCC CAAMIYLGYC FCGWIVLGPY HVKFRTLNMV
SECLFSLING DDMFATFAQM QQKSYLVWLF SRIYLYSFIS LFIYMVLSLF IALITDTYET
VKHYQQDGFP ETELRRFISQ CKDSPSSGKY RNMMTQSDLD LKEKALKEDL KFYFMNPCEK
YRARRQIPWK LALQILKILM VTTQLVFFGL SNQLVVSFKE ENIVAFKHLF LKGYSGTDED
DYSCSIYTQQ DAYDSIFYVI NQASKKAKCF IESGLLLYAA LTSFARSECI LLKPKELTDK
KAELKLNSSF FNLEFYRLIQ VEISFKLKGI ALQTIHAREL PDCYAFQNTI TFNNRAHSGK
IKIYFDSDTD IQECKDWHIF NSVLQKNTQY VLVFDGFVIL SCLASLILCT RSIVLAWRLQ
KRFVNFFLEK YKRRVCYADR LEFLNGWYVL VIISDVMTIV GSILKMEIKA KVLILTMQAS
LPKVLRFCCC AGMIYLGYTF CGWIVLGPYH EKFEDLNTVA ECLFSLVNGD DMFATFAQIQ
QKSSLVWMFS RLYLYSFISL FIYMILSLLL HSLLTPMTP
//
