ID A0A3M0K6N5_HIRRU Unreviewed; 587 AA.
AC A0A3M0K6N5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=DUI87_13857 {ECO:0000313|EMBL:RMC08863.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC08863.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC08863.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC08863.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC08863.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC08863.1}.
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DR EMBL; QRBI01000116; RMC08863.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0K6N5; -.
DR STRING; 333673.A0A3M0K6N5; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694:SF4; ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED; 1.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR Pfam; PF00692; dUTPase; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF51283; dUTPase-like; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00450};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00450}.
FT DOMAIN 349..390
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 418..523
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
SQ SEQUENCE 587 AA; 64658 MW; 501F765023036CEE CRC64;
MGSEGEMCSD TSFSPSPRAD GGLLGQLTAG TCGSAGLDVC TAAMVVLDSC GVHKVPLDAF
GPVGEGMSAF LMGRSSATIQ GIIGHLGLIE ADFKGQIYAM VSTPSPPSLS LKGPDLLNLC
LLSLLFTEQR TSCEETVALD PLGHWPSALT KDRPEKVCTL SIPGATDLPP RAPRHQCEHH
DSLPCHLVPG VALGAHADIC CRVGRNGTMR RGVHRDGFLM GATVMKGAEC PTPPIQWLVD
KPVWDNQWPL SQDKLDALHD LVQEQLQGHL ESSTSPWNTP VFCIKMSGKW RLLQDLRKVN
AMMESRLARV HSYYILHVRS HTNLPGFIAE GNVRADKLAN TVWVTPQPDT LVQAKASHGF
FHQNAHALQK QFQLMPTEAR DILESCDDFH TLAVPLPAGV NPRGLRALEI WQTDVTQIAE
FGRLKHTPSA VKTNNGPAYA SQKMRQFLQL WGVSHKFGIP HSLTDQVIVE HAYGTLKRVL
QKQNRGMQGE TPHSRLAKAL YTINHLMVLQ NSNNPVILNH HLSLQASDEM HQPRVKILGY
AGYQRSVFVL SCDCKGKIWP IGKLETLTKL KVIKWMNHQV LTHMQMM
//
