ID A0A3M0K728_HIRRU Unreviewed; 908 AA.
AC A0A3M0K728;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Ral guanine nucleotide dissociation stimulator-like 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_14614 {ECO:0000313|EMBL:RMC08371.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC08371.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC08371.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC08371.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC08371.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC08371.1}.
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DR EMBL; QRBI01000117; RMC08371.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0K728; -.
DR STRING; 333673.A0A3M0K728; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF199; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 2.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221}.
FT DOMAIN 65..214
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 250..568
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 837..905
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 594..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 100997 MW; 66BA82620F93335B CRC64;
MKLLWRAKMT TFQDGGEEVE DGAVYNVTLK KVQIQQAANK GARWLGGEGD QLPPEHTVRQ
YETSKIRAIK AGTLEKLVEN LLTAFGDADF SYISIFLATY RAFASPRAVL ELLLDRFGNL
ETSSHGEVAN LNSLESEMVL RAYSQFHLDA NTVFSLFTCS EVASVLRAWL DQCSEDFREP
PDYMCLLKLL DYLKNNMPNS DMESRVQNLL KQFQNQEVEA VDGFCSTSSS GLVDGEELEI
SNPEEFSSFQ DHVVAEQLTY MDVMLFRRVV PYHCLGSIWS QRDKKENKNL APTIRATITQ
FNAVTKCVIS TILGTRELKI QQRAKIIEKW INIAHECRIL KNFSSLRAII SALQSNSIYR
LKTTWMFVSK DVLLMYEELS EIFSDHDNYL TSRELLMKNW ETGLGIPKEQ ASYSVCGQMD
NKASSVWSSL TCALSWVNPS NLRSLKGEAT SKFANLDSSE KENQKKSQKR LQLQKNKGVM
QGTVPYLGTF LTDLIMLDTA LQDYVEGGLI NFEKRRREFE VIAQIKLLQS SCNSYCLIPD
QKFIQWFRRQ RHLTEEESYK LSREAEAAAD TNILSPKSQK SMVKRISTLF LGTDVFTPPK
EQPPKSSPAG GSSGESTDSA SVSSCEFNHS ETEDVCVTPV SSPEDPLKKI SGHPLSFCSP
DSSVRTPSSG LASLPSFLLA SNDDKSSVGS DKGYDSDKGS ISSDKGSSSK GSISDPASGS
DSGSIPTRDS VPSSAPRVLP VYNRQSEGSC IIRVSMDGLH DSVYKSILVS GTALGSAEVT
LGGTLNPSLP LENTPSLSWL IRPGWKGKTV HGAMQEPGGN EMFENSFREV SGVEIDVRIT
NQDRIPDVTQ RALLKHNLEP DAVEDYELVQ VISEDKELVF PRDANVFYGM NSHVNFDFIL
RKKAELVG
//
