ID A0A3M0KBP0_HIRRU Unreviewed; 586 AA.
AC A0A3M0KBP0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 03-MAY-2023, entry version 18.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:RMC10609.1};
GN ORFNames=DUI87_12320 {ECO:0000313|EMBL:RMC10609.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC10609.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC10609.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC10609.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC10609.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the HNF1 homeobox family.
CC {ECO:0000256|ARBA:ARBA00009966}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC10609.1}.
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DR EMBL; QRBI01000111; RMC10609.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0KBP0; -.
DR STRING; 333673.A0A3M0KBP0; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR023219; HNF1_dimer_N_dom_sf.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR11568; HEPATOCYTE NUCLEAR FACTOR 1; 1.
DR PANTHER; PTHR11568:SF2; HEPATOCYTE NUCLEAR FACTOR 1-BETA; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF100957; Dimerization cofactor of HNF-1 alpha; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..32
FT /note="HNF-p1"
FT /evidence="ECO:0000259|PROSITE:PS51937"
FT DOMAIN 91..186
FT /note="POU-specific atypical"
FT /evidence="ECO:0000259|PROSITE:PS51936"
FT DOMAIN 227..308
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 229..309
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 52..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 63654 MW; 39685ADDBB29B5CC CRC64;
MVSQLSALQR ELLGALLSSG ATKEGLIRAL EDMVPAAGFG VKLESLPLSP GGAPDGRAAL
PALANGHGKG KLSGDEGSED GDDFDTPQIL RELQSLNTEE AVEQRAEVER MISEDPWRAA
KMIKGYMQQH NIPQREVVDV TGLNQSHLSQ HLNKGTPMKT QKRAALYTWY VRKQREILRQ
FNQTVQGCGN RTDKGSQDQL LFLFPEFNQQ NQGAAQLDDA CSETPSKKMR RNRFKWGPAS
QQILYQAYER QKNPSKEERE TLVEECNRAE CLQRGVSPSK AHGLGSNLVT EVRVYNWFAN
RRKEEAFRQK LAMDAYSSGQ PPHSMNLLLS HGSPHHNQPS ASPPSKMPGV RYSQAASGEA
TSSGAISHHG SGAMVTTSQA VLQQVSPAGL DPGHGLLSPE GKMISVSGGG LPPVSTLTNI
HSLSHHNPQQ SQNLIMTPLS GVMAIAQSLN TSQAQSVPVI NSVAGSLAAL QPVQFSQQLH
SPHQQPLMQQ SPGHMTQQPF MATVTQLQNS HMYAHKQEPP QYSHTSRFPS AMVVTDTSSI
STLTNMSSSK QLMVNLVGST LPSAQGALVL VVPWTDGWMD GIRAVV
//
