ID A0A3M0KK50_HIRRU Unreviewed; 413 AA.
AC A0A3M0KK50;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Bone morphogenetic protein 3 {ECO:0000256|PIRNR:PIRNR037403};
GN ORFNames=DUI87_11705 {ECO:0000313|EMBL:RMC11584.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC11584.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC11584.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC11584.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC11584.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037403}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR037403,
CC ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC11584.1}.
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DR EMBL; QRBI01000108; RMC11584.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0KK50; -.
DR STRING; 333673.A0A3M0KK50; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR017197; BMP3/BMP3B.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR PANTHER; PTHR11848:SF145; GROWTH_DIFFERENTIATION FACTOR 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037403; BMP3/GDF10; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|PIRNR:PIRNR037403};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037403-1};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR037403};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 287..413
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 186..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 297..378
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 326..410
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 343..412
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 377
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
SQ SEQUENCE 413 AA; 47173 MW; A843D3A2F8C6205C CRC64;
MVAVHMLKLY EKYNREGSRP GDGNTVRSFK ARPEFLAQKP LYCFNLTSMQ DSEMILAATF
HFYADKRPRH REVFCKRSKN SSCRLLHLPP VLRLNLVFQS IHQNSAYGLV KGNITVLLQR
RGAWHAKDIS HIVKESKRAG ELILCAELDS GEKHQGFPEQ VASHLPYILV YANDLAISEP
NSVAGTLQRY DPFPPNDGDP NLSPNASTDT RVRRDTYLAS SIQNNELPEV DYNNNKYNKH
DIWENAYRSL KPKASRKDRR RKGQENTETL KKSQVLNFDE KTMKKARRKQ WNEPRICSRR
YMKVDFADIG WNEWIISPKS FDAYYCADIS GCTAGEDPCR ISCRFIAKNP IVRPSNHATI
QSIVKAVGII PGIPEPCCVP DKMSSLSVLF LDENKNVVLK VYPNMSVETC ACR
//
