ID A0A3M0KMN8_HIRRU Unreviewed; 838 AA.
AC A0A3M0KMN8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|PIRNR:PIRNR037595};
GN ORFNames=DUI87_08964 {ECO:0000313|EMBL:RMC13881.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC13881.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC13881.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC13881.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC13881.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC bacterial lipoproteins and other microbial cell wall components.
CC Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC13881.1}.
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DR EMBL; QRBI01000105; RMC13881.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0KMN8; -.
DR STRING; 333673.A0A3M0KMN8; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 643..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 693..836
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 95286 MW; DE045922509CDF38 CRC64;
MTSEQQRWQN EPGSSEGRYC DKDKKASGST GTSYMVFSES VITSKMSIQA KPKSRTTYTG
QVLTLYMVLA TNLSKQQGLK QACPSCDASQ ICNCSFMGLD FIPPGLTAEI TVLNLAHNRI
KHIQSQDLKQ AVNLRALLLQ SNKISSIEED SFQSLAKLEL LDLSNNSLVH LSPLWFGHLF
SLQHLHLQGN SYRDLGQSSP FSGLRNLTSL RLGNPQFSVI RQGNFEGIEL LHKLWIDASN
LSQYEQGSLK SIKVINHMII NLRNSNVFSE IVRDILHSVT LLEVVEIKFP VKIKSLVENS
TPPFRIQKLM LKEAFFTDQT ISRAIVSLKA ITSLKEVEAI DCVLQGQGLW NTEEIARSGK
SFVETVTIIR VIIQNFHLFI DLQGMEPQVN ELKRLTIASS NVFMVPCNLA RNFLSLLYLD
FHDNLLVNNR LNETICEGSW PALQTLNLSQ NSLKSLEQTA LYTSRLPKLN NLDISQNNFG
EIPDGCEWPK ALKYLNLSST QIPKVTMCIP ETLEVLDVSG NNLKEFGLEL PMLKELYLSR
NQLKTLPGAA PFPNLVALSV RRNKLNSFSK QEFESFKRME LLDASDNNFI CSCEFLSFIH
HEAGIARVLV GWPDKYVCDS PLAVRGAQVG AVHLSLMECH RSLVVSLICV LVFLVVLVLV
AVGYKYHVVW YLRMTWAWLQ AKRKPKRAPP KDVCYDAFVS YSENDSDWVE NTMVQELEQA
CPPFRLCLHK RDFVPGKWIV DNIIDSIEKS HKTLFVLSER FVQSEWCKYE LDFSHFRLFD
ENNDAAILIL LEPIQSKAIP KRFCKLRKIM NTKTYLEWPA GEEQQQVFWE NLKEALKS
//