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Database: UniProt
Entry: A0A3M0KMN8_HIRRU
LinkDB: A0A3M0KMN8_HIRRU
Original site: A0A3M0KMN8_HIRRU 
ID   A0A3M0KMN8_HIRRU        Unreviewed;       838 AA.
AC   A0A3M0KMN8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Toll-like receptor 2 {ECO:0000256|PIRNR:PIRNR037595};
GN   ORFNames=DUI87_08964 {ECO:0000313|EMBL:RMC13881.1};
OS   Hirundo rustica rustica.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC   Hirundo.
OX   NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC13881.1, ECO:0000313|Proteomes:UP000269221};
RN   [1] {ECO:0000313|EMBL:RMC13881.1, ECO:0000313|Proteomes:UP000269221}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Chelidonia {ECO:0000313|EMBL:RMC13881.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:RMC13881.1};
RA   Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA   Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT   "A high quality draft genome assembly of the barn swallow (H. rustica
RT   rustica).";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC       bacterial lipoproteins and other microbial cell wall components.
CC       Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC       bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC       leading to NF-kappa-B activation, cytokine secretion and the
CC       inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMC13881.1}.
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DR   EMBL; QRBI01000105; RMC13881.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M0KMN8; -.
DR   STRING; 333673.A0A3M0KMN8; -.
DR   Proteomes; UP000269221; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF01582; TIR; 1.
DR   PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00364; LRR_BAC; 6.
DR   SMART; SM00369; LRR_TYP; 9.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS51450; LRR; 4.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW   ECO:0000256|PIRNR:PIRNR037595};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW   ECO:0000256|PIRNR:PIRNR037595};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW   Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        643..664
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          693..836
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   838 AA;  95286 MW;  DE045922509CDF38 CRC64;
     MTSEQQRWQN EPGSSEGRYC DKDKKASGST GTSYMVFSES VITSKMSIQA KPKSRTTYTG
     QVLTLYMVLA TNLSKQQGLK QACPSCDASQ ICNCSFMGLD FIPPGLTAEI TVLNLAHNRI
     KHIQSQDLKQ AVNLRALLLQ SNKISSIEED SFQSLAKLEL LDLSNNSLVH LSPLWFGHLF
     SLQHLHLQGN SYRDLGQSSP FSGLRNLTSL RLGNPQFSVI RQGNFEGIEL LHKLWIDASN
     LSQYEQGSLK SIKVINHMII NLRNSNVFSE IVRDILHSVT LLEVVEIKFP VKIKSLVENS
     TPPFRIQKLM LKEAFFTDQT ISRAIVSLKA ITSLKEVEAI DCVLQGQGLW NTEEIARSGK
     SFVETVTIIR VIIQNFHLFI DLQGMEPQVN ELKRLTIASS NVFMVPCNLA RNFLSLLYLD
     FHDNLLVNNR LNETICEGSW PALQTLNLSQ NSLKSLEQTA LYTSRLPKLN NLDISQNNFG
     EIPDGCEWPK ALKYLNLSST QIPKVTMCIP ETLEVLDVSG NNLKEFGLEL PMLKELYLSR
     NQLKTLPGAA PFPNLVALSV RRNKLNSFSK QEFESFKRME LLDASDNNFI CSCEFLSFIH
     HEAGIARVLV GWPDKYVCDS PLAVRGAQVG AVHLSLMECH RSLVVSLICV LVFLVVLVLV
     AVGYKYHVVW YLRMTWAWLQ AKRKPKRAPP KDVCYDAFVS YSENDSDWVE NTMVQELEQA
     CPPFRLCLHK RDFVPGKWIV DNIIDSIEKS HKTLFVLSER FVQSEWCKYE LDFSHFRLFD
     ENNDAAILIL LEPIQSKAIP KRFCKLRKIM NTKTYLEWPA GEEQQQVFWE NLKEALKS
//
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