ID A0A3M0KRB0_HIRRU Unreviewed; 794 AA.
AC A0A3M0KRB0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Fibrinogen alpha chain {ECO:0000256|ARBA:ARBA00017850};
GN ORFNames=DUI87_08957 {ECO:0000313|EMBL:RMC13874.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC13874.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC13874.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC13874.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC13874.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC head to head conformation with the N-termini in a small central domain.
CC {ECO:0000256|ARBA:ARBA00025974}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC13874.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QRBI01000105; RMC13874.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0KRB0; -.
DR STRING; 333673.A0A3M0KRB0; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0030168; P:platelet activation; IEA:InterPro.
DR GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 1.20.5.50; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR InterPro; IPR037579; Fibrinogen.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR InterPro; IPR021996; Fibrinogen_aC.
DR InterPro; IPR020837; Fibrinogen_CS.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR PANTHER; PTHR47221:SF3; FIBRINOGEN ALPHA CHAIN; 1.
DR Pfam; PF08702; Fib_alpha; 1.
DR Pfam; PF12160; Fibrinogen_aC; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SMART; SM01212; Fib_alpha; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 551..792
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 299..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 794 AA; 88396 MW; E3A07722A935381C CRC64;
MRAESKGEWS LRQSIQRRIM NEQSQKLSFF EFEWEIFHGP QYILFDTNMQ AQDGESTFEQ
VGAGVRGPRI VEHKSPSSCQ SEKSWPICAD DDWGTKCPSG CRMQGLIDEK DQEFSHRIDK
IKKLLSDNQN NYKKSNQIIV ETVNALKPNL DSAQELDETY GRLSGELRRR IVTLKQRVVT
QVNRIKALQS SIQEQVVEMK RLEVDIDIKI RACKGTCARS FDYKVDKESY DNIQKQLAQA
NSINLHPELQ TTTLSTLKMR PLKDSNVPDH FKHKPLPEMQ ALNIINNIKQ MEVVLERPGT
DAKLSRGDSS YHTAESRGDE PSHTSKLVIP THGRETLSLG DKTSSTVRRC TKTTTKKIVS
GPDGPREEVV ERTVSSDGSD CSYLAGNVGG EGSTYHFSGA DGLHKLETVF PELESFFTPD
SPSTATKHVS GSSSFTTSRH TTGTGSSHIG TGVSSHSGTY GGKDKLGDLG DEEEDDFGRL
QPSGLPSGSA SHSKTVATSS SSFKNKGGSF ETKSVKIREI NERLGGLEHD QSAEDTPDFQ
ARSFRPSGGK RRTPSTGKDC DDIRQKHTSG AKSGIFKIKP AGSNKVLSVY CDQETTLGGW
LLIQQRMDGS VNFNRTWQDY KKGFGSVDGR GQGEFWLGNE NLHLLTQNGT LLRVELEDWD
GNAVFAEYLV QVGSEAEGYT LAVSSYEGTA GDALIAGWLE EGTEYTSHAQ MKFSTFDRDQ
DHWEENCAEM YGGGWWYNSC QAANLNGIYY PGGHYDPRYN VPYEIENGVV WLPFKASDYS
LKTVRMKIRP IETL
//
