ID A0A3M0KRD3_HIRRU Unreviewed; 1677 AA.
AC A0A3M0KRD3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=DUI87_08987 {ECO:0000313|EMBL:RMC13904.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC13904.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC13904.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC13904.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC13904.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC13904.1}.
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DR EMBL; QRBI01000105; RMC13904.1; -; Genomic_DNA.
DR STRING; 333673.A0A3M0KRD3; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 9.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF12; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4 ISOFORM X1; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 9.
DR SMART; SM00135; LY; 12.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 9.
DR PROSITE; PS51120; LDLRB; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1580..1604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 213..249
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 380..425
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1106..1149
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1613..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 25..37
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 71..89
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 83..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 120..135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 140..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 147..165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 159..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 177..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 184..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 775..790
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 814..829
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 834..846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 841..859
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 853..868
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 896..911
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1677 AA; 182112 MW; A38F571CEB0883DB CRC64;
MPAAAVPPDP GPGSLLPAAT ASPTCAASRQ ADCVFGCIPV PWLCDGEQQC PDGTDEQCDV
ACGGDPHVWQ CDDGRCVSSS WRCDGAPDCL DGSDERDCVC GTKKVQCPGT HHCIPHWELC
DRHQDCEDGW DEEGCPQQPC LPGQWQCRNR VCIMAEWKCN GIDDCGDSSD EDVCAPCTPG
MVRCDEGKCI LESLMCDDKD DCLDGTDEPS TCDVDECSLE YSPCSQLCTN TPGTFSCACL
QGYTLRHGTA CEVADNATQI LVAVGQDLAL LDVRTQAYRP LLSTETEPRA LVYDLLRETY
YWLTEDGELR VHRPGKGTQP LYADAREVNS ISMDWFTGQL YWASSHPPAI CAGLGDGRGY
VTVLGKDIAP EQLTVHPAAR SLYWVNRGQR GRTVIAAAGM DGSNRRELTV VSMEEPVGLS
LDHVAGRLYW ISEYKESIET LRVDGSGRHS FHAVLRSHTE PLGLAVFESR FFWTDGTELV
SATWASPQEH AVLLRASISA FTVLHALQQP PKLSIVYASG KAISLVHVGP GAHTKQVQEW
QEPLHLQDVD WQRSVLYGTD DRGTLLRVVG HPGRREAIVT GLPVCSACVD IRSGDLYWLA
CNRRDIGVIQ TSDASPRILH RARSSIQHLF LDWQRGALYW LARGQPLQAL SLTGGAPRDA
WNETWPGDLP AAMDSRAFSI LWSSALGLQA LSLTKRQAAT LAPSWSHGLM AAFEPYLVSA
NGTALLLWDR RTLALVLSMP AAGVQGVVAF VGSELQAGAF HCASGAVCVG AGERCDGVPQ
CPDGSDETGC WTPTQECALR CDAATRCIPR SWLCDGHADC LDHTDEQGCV LKECGPAEFS
CRSGQCVALA LHCDGDHDCQ DGSDEEGCAV PRPLLCREGE VTCSRSGECV PGAWRCDGAA
DCGDGSDEQR CWCGPGYRLA EDGLSCKDID ECTEWGKGPC SQTCLNAPGS YSCGCLPGYL
LEPDGHVCKL TGPEPKLLVA VQSKVLSYGL RSGHEEVVLA TDKDRVVFSL DYDLVEKKVF
WMDLATESIR WQDLSSGKKG TLVKGVRSDC IAVDWLGRNL YWTDGVAGQV LATRLGSAWQ
GIPEYTVVMD GDLDQPHSLV LQPLAGLMYW SEVGSHSRLM EASMDGSWRH VLLAQGLGWP
TALALDLPTQ RIFWLDEKLG SVGSADLDGS SVKVLKLPWV RNPFAAAVCE GQLYWSERKT
WSVQQVDKAS GKNRTVLLKR HGQPHGLQVM HPALRPAGPN PCETRGCSHL CLLSARHTGQ
CRCPAGLMLA ANETTCLPIR DSAFALLVSP AAVAQVYLKD LPTSAGSQGP PPHQALPLAK
VSRLTAIDYA VKDKSLYFAE VGGNSIGLLR LKDWGRLSWK KAVAVEGTVT SLALDWLSGN
LYWIGGQPPS IHVAAPRGRW ALALLSKGLQ GAAWLALCPG ASTMCFVTAA GSHGHGAVVE
CAAMDGTGRR VVWRRARAPT GLAFGGAGTR LYWADHERGT ISSVELDGSR FRLVREGLHG
LSLFAVGEGF LLWSTTSTNG SSKIWHSRLE RAENWWFPME QELVAMRIYS EFSQEGRPSD
LPLRPGLSRD YCEEAEVQPL AGPVALGVTV LLLLAAAAVG ALAYMRRRDR RRRTSSTAST
RVLTLYHRES DPEEEDEEEE EELPPKSDTF VNEAYEGKEE LPALLRKGPS HINTVFS
//
