ID A0A3M0KU56_HIRRU Unreviewed; 834 AA.
AC A0A3M0KU56;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Zinc fingers and homeoboxes protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_07101 {ECO:0000313|EMBL:RMC14924.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC14924.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC14924.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC14924.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC14924.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC14924.1}.
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DR EMBL; QRBI01000104; RMC14924.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0KU56; -.
DR STRING; 333673.A0A3M0KU56; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 4.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15467:SF5; ZINC FINGERS AND HOMEOBOXES PROTEIN 2; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 3.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 4.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 109..137
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 284..323
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 447..497
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 537..581
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 636..686
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 286..324
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 449..498
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 539..582
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 638..687
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 504..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 92612 MW; 2932132A89277157 CRC64;
MGRGRAAAVV GEAGKQMDEA GITRGVQELE FHKSLICECG AWQIHTWSVS CMGNCFMLGF
ERIELEAVIP ALIPSWSCFL WQYTLLSFHM YRNEHVDTQH PNVILNPLYV CAECNFTTKK
YDSLSDHNAK YHPGETNFKL KLIKRNNQTV LEQSIETTTN DVTVTSSGLE NAEYDDSLHG
GIGASKVPVM KVGKPKGETK KGCKKPEEGV TENHVDGAVP RIITEATEAI ACINGDLLQD
VLAHVMPSVQ LPPNINLVPK VPVPLNSTKY NSALDTNATM INSFNKFPYP TQAELSWLTA
ASKHPEEQIR IWFATQRLKH GISWSPEEVE EARKKMFNGT IQAVPQTITV LPAPLATAKM
PQPIIQTALP CQILGQTGLV LTPVSNGSTV SCSPITLAVA PNQGQKRTIQ TLSSAPEAKR
PHVVQVPEIP AKLTAVPVTP ASERKKTKEQ IAELKASFMA SQFPDDAEVY RLIEATGLSR
SEIKKWFSDH RYRSQRGIVQ IPGDALGKDQ TAPSAGRHGR SFHPYTDFTP QRFKEKTQEQ
LRALEESFLK CSFPTQGELD RLRVETKLSR REIDSWFSER RKIRDSMEQA VLDSMGSYRK
IKDQGTPNGA ISQAELLSSS QLPGALSGSS PTLKKTQEQI HLLKSTFART QWPSPQEYDQ
LASQTGLTRT EIVRWFKENR SSLRTGSLKW IDQYQQQYAG DGHNKQSQKK SSKHVESPKN
GNEVSRQHYQ ECKKLNEENG GKPVVRAKRD CEPLKDSLLG NQAEGVERLE CHSHDGHGSE
ENEEPAEVSW VEVTVGEDDA ASDCTDSWSQ TAPEGHTELA DLDSESISGD TSHV
//
