ID   A0A3M0L2M8_HIRRU        Unreviewed;       507 AA.
AC   A0A3M0L2M8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999};
GN   ORFNames=DUI87_03259 {ECO:0000313|EMBL:RMC19695.1};
OS   Hirundo rustica rustica.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC   Hirundo.
OX   NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC19695.1, ECO:0000313|Proteomes:UP000269221};
RN   [1] {ECO:0000313|EMBL:RMC19695.1, ECO:0000313|Proteomes:UP000269221}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Chelidonia {ECO:0000313|EMBL:RMC19695.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:RMC19695.1};
RA   Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA   Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT   "A high quality draft genome assembly of the barn swallow (H. rustica
RT   rustica).";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome
CC       membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Recycling endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004195}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMC19695.1}.
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DR   EMBL; QRBI01000094; RMC19695.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M0L2M8; -.
DR   STRING; 333673.A0A3M0L2M8; -.
DR   Proteomes; UP000269221; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0051453; P:regulation of intracellular pH; IEA:UniProt.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   InterPro; IPR002090; NHE-6/7/9.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF94; SODIUM_HYDROGEN EXCHANGER 6; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 2.
DR   PRINTS; PR01084; NAHEXCHNGR.
DR   PRINTS; PR01088; NAHEXCHNGR6.
PE   4: Predicted;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        51..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        226..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        262..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        325..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        436..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          57..322
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   DOMAIN          332..399
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   507 AA;  55395 MW;  89514FCBF489C114 CRC64;
     MAGPGPVLAA AAGLWARGAG GAEVAAARPG ALDEEIVSEK AAEESHRQDS ANLLVFILLL
     TLTILTIWLF KHRRARFLHE TGLAMIYGVL VGVVLRYGIH VPSNVNNVTL SCQVQTSPAT
     LLVNVSGKFY EYTLKGEISA QELNNVQDNE MLRKVTFDPE VFFNILLPPI IFYAGYSLKR
     RHFFRNLGSI LAYAFLGTAI SCLVIGSVVY GCVVLMKVTG QLGGDFYFTD CLLFGAIVSA
     TDPVTVLAIF HELQVDVELY ALLFGESVLN DAVAIVLSSS IVAYQPAGDN SHTFDVTAMF
     KSIGIFLGIF SGSFAMGAAT GVESYVMLCS PGVVAVLFCG ITQAHYTYNN LSTESQYRTK
     QLFELLNFLA ENFIFSYMGL ALFTFQNHVF NPTFVVGAFA DANRNKGPGL RGAMAFALAI
     RDTATYARQM MFSTTLLIVF FTVWVFGGGT TAMLSCLNIW VGVDADQENV GVPENERRST
     KAESAWVFRM WYNFDHKMLL CSIKLGA
//