ID A0A3M0L5R7_HIRRU Unreviewed; 952 AA.
AC A0A3M0L5R7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN ORFNames=DUI87_01271 {ECO:0000313|EMBL:RMC20421.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC20421.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC20421.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC20421.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC20421.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC20421.1}.
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DR EMBL; QRBI01000093; RMC20421.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0L5R7; -.
DR STRING; 333673.A0A3M0L5R7; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR33064:SF29; LRRGT00076; 1.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221}.
FT DOMAIN 138..319
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 571..720
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 783..952
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
SQ SEQUENCE 952 AA; 107514 MW; E62569224E38E915 CRC64;
MPSRYVGTES ISISGVTGGS QQLTVLEAEV SLTGNGWQKH PIVTGPEAPC ILGIDYLRNG
YFKDPKGYRW AFGIAAVETE DIRQLSTLPG LSDDSCAVGL LRVEEQQVPI ATTTVHRRQY
RTDRDSVTPI HEMIRKLESQ GVVSKARSPF NSPIWPVRKS SGEWRLTVDY RALNEVTPPL
SAAVPDMLEL QYELESKAAK WYATIDIANA FFSIPLAAEC RAQFAFTWKG IQYTWNRLPQ
GWKHSPTICH GLIQTALEKG EAPEHLQYID DIIVWGNTAG EVFEKGEKII QILLKAGFAI
KRSKVKGPAQ EIQFLGVKWQ DGRRQIPTEV INKIIAMSPP TSKKETQAFL GAIGFWRMHI
PEYSQIVSPL YLVTRKKNDF HWGPEQQQAF AQIKQEIAHA VALGPVRTGP EVKNVLYSAA
GSNGLSWSLW QKVPGETRGR PLGFWSRSYR GSEANYTPTE KEILAAYEGL QAASEVIGTE
TQLLLAPRLP VLGWMFKGKV PSTHHATDTT WSKWIALITQ RARIGNPNRP GILEIITNWP
EGETFGLSFE EEEEQVTRAE EAPPYNELPE TERQYALFTD GSCRIVGANR KWKAAVWSPT
RRVAQATEGQ GGSSQIAELK AIQLALDIAE REKWPRLYLY TDSWMVANAL WGWLNRWKKA
NWQRRGKPIW AAEIWQDIAA RVEKLTVKVR HVDAHVSKSQ ANEEHHNNEQ VDKAAKVKVS
QVDLDWQHKG EVFLARWAHD ASGHQGRDAT YRWARDRGVD LTMDNISQVI HNCETCAAIK
QAKRVKPLWY GGRWLKYRYG EAWQIDYITL PQTRQGKRYV LTMVEATTGW LETYPVPHAT
ARNTILGLEK QVLWRHGTPE RIESDNGTHF KNGLINTWAR EHGIEWIYHI PYHAPAAGKV
ERCNGLLKTT LKALGGGTFK NWELNLAKAT WMVNTRGSIN RAGPASLNPC TQ
//
