ID A0A3M0LBD1_HIRRU Unreviewed; 386 AA.
AC A0A3M0LBD1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN ORFNames=DUI87_00658 {ECO:0000313|EMBL:RMC22346.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC22346.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC22346.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC22346.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC22346.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC22346.1}.
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DR EMBL; QRBI01000092; RMC22346.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0LBD1; -.
DR STRING; 333673.A0A3M0LBD1; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR010661; RVT_thumb.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF06817; RVT_thumb; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000269221}.
FT DOMAIN 119..308
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 386 AA; 43980 MW; 7C0A85CFAF5CED56 CRC64;
MWPSYWDLKP IASKLQAIGG LQLVKISKNI VQVEGLDGKL ASGHPFVIDY KAPLWGRDTM
SQWGSNLLSL KPPRIFRGGH CGAPYSKLTW LDDTPVWVNQ WPLSKEKLKA LKELIEEQFA
KGHIEKTTSP WNSPVFVIKK PGKDKWRLLH DLWEISKVIE DMGSLQPGMN SPTMLPRNWQ
LVVLDIKDCF FQIPLHPEDA PWFEYSVPTI NREAPMKCYP WKVLPQGMKC SPSICQGYVA
SLLSPVHAER REAIILHYTD DVLMCAPNDT ILQHTLDLVV KVLTSAGFHL QEDKVQRVPP
WKYLGLEITA RTVVPQKLEI KSDPKTLADL HSLCGSLNWV RPWLSITNKD LDPLKNLLRG
ERELISPREL TPEAKTPIKK AQKSFN
//
