ID   A0A3M0LH02_HIRRU        Unreviewed;       790 AA.
AC   A0A3M0LH02;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   13-SEP-2023, entry version 13.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=DUI87_04243 {ECO:0000313|EMBL:RMC18357.1};
OS   Hirundo rustica rustica.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Hirundinidae;
OC   Hirundo.
OX   NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC18357.1, ECO:0000313|Proteomes:UP000269221};
RN   [1] {ECO:0000313|EMBL:RMC18357.1, ECO:0000313|Proteomes:UP000269221}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Chelidonia {ECO:0000313|EMBL:RMC18357.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:RMC18357.1};
RA   Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA   Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT   "A high quality draft genome assembly of the barn swallow (H. rustica
RT   rustica).";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMC18357.1}.
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DR   EMBL; QRBI01000096; RMC18357.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M0LH02; -.
DR   STRING; 333673.A0A3M0LH02; -.
DR   Proteomes; UP000269221; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 6.20.120.20; -; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          153..254
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          422..757
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   790 AA;  87475 MW;  E6B879E00F501E9E CRC64;
     MAAGAVWVPA VGSGAAVAGR SGWIPAVGSG AAVAGGSGWI RAVGSGAAVA GGSGSRRGGA
     GWRPRFTVPV SGRAVRRRGG PWRTAAATEL PAWRLRCEGG RQLWRYLGDG DVGERRAQTA
     LEQHSLGLDT SATLQALPAA GSAREAARNG MRFYAALQAE DGHWAGDYGG PLFLLPGLLI
     TCHTAKIQLP EAFRKEMVRY LRSVQLPDGG WGLHVEDKST VFGTALNYVA LRILGLGPDD
     PDIVRARVNL HNKGQPWGWY TAHPSRLWCH CRQVYLPMSY CYAKRLSAEE DELIRSLRQE
     LYVQDYGSID WPAQRSNVAA CDVYTPHSWL LGAAYAVMNM YEAHHSTHLR QRAVTELYDH
     IKADDRFTKC ISIGPISKTI NMLVRWFVEG KDSPAFQEHV SRIPDYLWLG LDGMKMQGTN
     GSQLWDTAFA IQAFLEAEAQ EMPEFTSCLQ NAHGFLRFSQ IPENPPDYQK YYRHMNKGGF
     PFSTRDCGWI VADCTAEGLK AVMLLQEKCP FIAKPVPAER LFDAVNVLLS MRNSDGGFAT
     YETKRGGHLL ELLNPSEVFG DIMIDYTYVE CTSAVMQALR HFQSQFPEHR AGEIRETLQK
     GLDFCRKKQR ADGSWEGSWG VCFTYGTWFG LEAFASMQHT YKNGTVCREV AQACQFLISK
     QMADGGWGED FESCEQRTYV QSAESQIHNT CWALLGLMAV RYPDIGVLER GIKVLMDKQL
     PNGDWPQENI AGVFNKSCAI SYTAYRNIFP IWTLGRFCRL HPKSPLVGQL PARARPSAGA
     AQEEQGALSA
//