ID A0A3M2HHB9_9GAMM Unreviewed; 785 AA.
AC A0A3M2HHB9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=phosphomannomutase {ECO:0000256|ARBA:ARBA00012730};
DE EC=5.4.2.8 {ECO:0000256|ARBA:ARBA00012730};
GN ORFNames=EBB59_10775 {ECO:0000313|EMBL:RMH89106.1};
OS Lysobacter pythonis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Lysobacter.
OX NCBI_TaxID=2483112 {ECO:0000313|EMBL:RMH89106.1, ECO:0000313|Proteomes:UP000275012};
RN [1] {ECO:0000313|EMBL:RMH89106.1, ECO:0000313|Proteomes:UP000275012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4284/11 {ECO:0000313|EMBL:RMH89106.1,
RC ECO:0000313|Proteomes:UP000275012};
RA Hans-Juergen B., Huptas C., Sandra B., Igor L., Joachim S., Siegfried S.,
RA Mareike W., Peter K.;
RT "Proposal of Lysobacter pythonis sp. nov. isolated from royal pythons
RT (Python regius).";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate = D-mannose 6-phosphate;
CC Xref=Rhea:RHEA:11140, ChEBI:CHEBI:58409, ChEBI:CHEBI:58735;
CC EC=5.4.2.8; Evidence={ECO:0000256|ARBA:ARBA00000586};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate:
CC step 2/2. {ECO:0000256|ARBA:ARBA00004699}.
CC -!- SIMILARITY: Belongs to the phosphohexose mutase family.
CC {ECO:0000256|ARBA:ARBA00010231}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMH89106.1}.
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DR EMBL; RFLY01000016; RMH89106.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M2HHB9; -.
DR OrthoDB; 9803322at2; -.
DR Proteomes; UP000275012; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016868; F:intramolecular phosphotransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd03089; PMM_PGM; 1.
DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 3.
DR Gene3D; 3.30.310.50; Alpha-D-phosphohexomutase, C-terminal domain; 1.
DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR InterPro; IPR005846; A-D-PHexomutase_a/b/a-III.
DR InterPro; IPR005843; A-D-PHexomutase_C.
DR InterPro; IPR036900; A-D-PHexomutase_C_sf.
DR InterPro; IPR005841; Alpha-D-phosphohexomutase_SF.
DR PANTHER; PTHR43771:SF2; PHOSPHOGLUCOMUTASE; 1.
DR PANTHER; PTHR43771; PHOSPHOMANNOMUTASE; 1.
DR Pfam; PF02878; PGM_PMM_I; 1.
DR Pfam; PF02879; PGM_PMM_II; 1.
DR Pfam; PF02880; PGM_PMM_III; 1.
DR Pfam; PF00408; PGM_PMM_IV; 1.
DR PRINTS; PR00509; PGMPMM.
DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1.
DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 3.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000275012};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 241..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..463
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
FT DOMAIN 482..579
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02879"
FT DOMAIN 584..688
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02880"
FT DOMAIN 700..774
FT /note="Alpha-D-phosphohexomutase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00408"
SQ SEQUENCE 785 AA; 83175 MW; 2292996817A01C0A CRC64;
MAIKINRQSL PKLQMGSPEE ARRALTLMAV LCGLLALWFM WSGLRLWWAQ AADEALMFER
DRVAGEIGHQ FGALSAQVVE AVAKPEVAEA LKAGDREAAA ALTAALPKAA AVEVYPADLG
AFYDKLPETG YGKLAVVEEV QMAGKPVMRV GRSGAGGMLL AGVPLPEGAA ALAAFPLTEA
NRLIATVKTG NGYIALRQGM VNVIQDGDPA LAGTSEANAA PVRGGGFRIA IGLPTAEAGP
YGLGALACGA IGLLLAIVAG LLLAWPRLNR RRPAAVVDEA EAPTLGETLA AAPLTQAEGR
GRVSLADRMG MEEIEMSQDS NVAAGLAPER LDRDIFRAYD IRGVVGQGLD AEVARAIGQA
VGSLMREQGL SDIVVGRDGR LSGPALSAAL IEGLRSTGRK VIDIGLAPTP LVYFAAYHLR
AGSCVAVTGS HNPPDYNGFK IVVGGETLSG EAIVALYQRI VEGRLYRAAG PGALETRDAA
GDYLQRVAAD IQLGRPLRVV VDAGNGAAGD LGPKVLEAIG AEVEPLYCEI DGHFPNHHPD
PSDPHNLADL TQAVQRSGAD IGLAFDGDGD RLGVVTPAGR NVFPDRLLML FAADVLERQP
GAVIVYDVKC TGALMPWVLR HGGSPLMWKT GHSFIKAKMR ETDAELAGEM SGHFFFKERW
YGFDDGIYSA ARLLEILAAR TDDADTVFAG IPEGISTPEL KIPVEDPHAF IERFVAMGDF
AEARSNTIDG LRADWKNGWG LVRASNTTPI LVLRFEAVDE PALREIQEAF RERLLALEPA
LDIPF
//
