ID A0A3M2I483_9GAMM Unreviewed; 959 AA.
AC A0A3M2I483;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316, ECO:0000256|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000256|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156, ECO:0000256|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000256|HAMAP-Rule:MF_00205,
GN ECO:0000313|EMBL:RMH94419.1};
GN ORFNames=EBB59_01620 {ECO:0000313|EMBL:RMH94419.1};
OS Lysobacter pythonis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Lysobacter.
OX NCBI_TaxID=2483112 {ECO:0000313|EMBL:RMH94419.1, ECO:0000313|Proteomes:UP000275012};
RN [1] {ECO:0000313|EMBL:RMH94419.1, ECO:0000313|Proteomes:UP000275012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4284/11 {ECO:0000313|EMBL:RMH94419.1,
RC ECO:0000313|Proteomes:UP000275012};
RA Hans-Juergen B., Huptas C., Sandra B., Igor L., Joachim S., Siegfried S.,
RA Mareike W., Peter K.;
RT "Proposal of Lysobacter pythonis sp. nov. isolated from royal pythons
RT (Python regius).";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000, ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMH94419.1}.
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DR EMBL; RFLY01000002; RMH94419.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M2I483; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000275012; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd03270; ABC_UvrA_I; 1.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 3.30.190.20; -; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00205};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00205}; Reference proteome {ECO:0000313|Proteomes:UP000275012};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_00205};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP-
KW Rule:MF_00205}.
FT DOMAIN 613..943
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT ZN_FING 260..287
FT /note="C4-type"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT ZN_FING 746..772
FT /note="C4-type"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 647..654
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
SQ SEQUENCE 959 AA; 105958 MW; 6BC84C01E33036BB CRC64;
MALDTIRIRG ARTHNLKNFD LDLPRDKLIV ITGLSGSGKS SLAFDTIYAE GQRRYVESLS
AYARQFLSVM EKPDLDHIEG LSPAISIEQK STSHNPRSTV GTITEVYDYL RLLYARVGIP
RCPDHHFPLE AQTVSQMVDQ VLALAGDPGS SGQRFMLLAP VVRERKGEHA QVFEQLRAQG
YVRVRVDGDL HEIDAVPPLA LRQKHTIEAV IDRFKVREDM QQRLAESFET ALKLGEGMAI
VRSLDDARAE PLLFSSKYSC PVCDYALPEL EPRLFSFNAP MGACETCDGL GVAQFFDPAR
VVTHPELSLA AGAVRGWDRR NTYYFQMLQS LAKHYGFKVD TPWQALPEYI RQAVLHGSGE
ENIAFTYLND AGSRTTRKHR FEGIIPNLER RYRDTESNAV REELAKYISE RPCPDCNGAR
LNRAARNVFV GERPIHEVTQ QPIDEALAFF STLKLPGWRG EIAAKIVKEI GERLGFLVDV
GLDYLTLERK ADTLSGGEAQ RIRLASQIGA GLVGVMYVLD EPSIGLHQRD NERLLGTLTR
LRDLGNTVIV VEHDEDAIRL ADHVVDIGPG AGVHGGEVIA QGDVKAIIAS ERSLTGDYLS
GRKAIEIPAK RHAPSKKFML KLKGASGNNL RNVDLEIPAG LMTAITGVSG SGKSTLINDT
LYALAANEIN GASHTPAAHK EIKGLDLFDK VVDIDQSPIG RTPRSNPATY TGLFTPLREL
FSQVPEARAR GYAPGRFSFN VRGGRCEACQ GDGLIKVEMH FLPDVYVPCD VCGGKRYNRE
TLEIVYKGHS IHDVLEMTVE DAAKLFENVP AISRKLDTLI DVGLAYIKLG QSATTLSGGE
AQRVKLSKEL SRRDTGRTLY ILDEPTTGLH FADIEHLLTV LHRLRDEGNT VVVIEHNLDV
IKTADWIVDL GPEGGHRGGE IIATGTPETL AQLPHSHTGR FLAKQMEEDA RRAKHRKNA
//
