ID A0A3M2KXP4_9NOCA Unreviewed; 204 AA.
AC A0A3M2KXP4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=4-hydroxy-2-oxohexanoate aldolase {ECO:0000256|ARBA:ARBA00023631};
DE EC=4.1.3.43 {ECO:0000256|ARBA:ARBA00023622};
DE Flags: Fragment;
GN Name=dmpG {ECO:0000313|EMBL:RMI29416.1};
GN ORFNames=EBN03_25350 {ECO:0000313|EMBL:RMI29416.1};
OS Nocardia stercoris.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=2483361 {ECO:0000313|EMBL:RMI29416.1, ECO:0000313|Proteomes:UP000279275};
RN [1] {ECO:0000313|EMBL:RMI29416.1, ECO:0000313|Proteomes:UP000279275}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEAU-LL90 {ECO:0000313|EMBL:RMI29416.1,
RC ECO:0000313|Proteomes:UP000279275};
RA Ling L.;
RT "Isolation from cow dung.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate;
CC Xref=Rhea:RHEA:36003, ChEBI:CHEBI:15361, ChEBI:CHEBI:17153,
CC ChEBI:CHEBI:73142; EC=4.1.3.43;
CC Evidence={ECO:0000256|ARBA:ARBA00023518};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36004;
CC Evidence={ECO:0000256|ARBA:ARBA00023518};
CC -!- SIMILARITY: Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
CC {ECO:0000256|ARBA:ARBA00008944}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMI29416.1}.
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DR EMBL; RFFH01000014; RMI29416.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M2KXP4; -.
DR OrthoDB; 9803573at2; -.
DR Proteomes; UP000279275; Unassembled WGS sequence.
DR GO; GO:0008701; F:4-hydroxy-2-oxovalerate aldolase activity; IEA:InterPro.
DR GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR017629; 4OH_2_O-val_aldolase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR012425; DmpG_comm.
DR InterPro; IPR000891; PYR_CT.
DR NCBIfam; TIGR03217; 4OH_2_O_val_ald; 1.
DR PANTHER; PTHR10277:SF9; 2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR10277; HOMOCITRATE SYNTHASE-RELATED; 1.
DR Pfam; PF07836; DmpG_comm; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF89000; post-HMGL domain-like; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Aromatic hydrocarbons catabolism {ECO:0000256|ARBA:ARBA00022797};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:RMI29416.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Reference proteome {ECO:0000313|Proteomes:UP000279275}.
FT DOMAIN 1..120
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RMI29416.1"
SQ SEQUENCE 204 AA; 21636 MW; 50E363C46FEAD9CA CRC64;
MSHTQPPEAL AKQARIMADA GCQCVYVVDS AGALVLEGVS DRIAAVVAEL GDDAQVGFHG
HENLDLAVAN SVYAVRAGAK QIAGSARRFG AGAGNTPVEA FVGVCDKLNI KTGIDFFKIA
DAAEDVVRPV MPAECLLDRQ SLMMGYAGVY SSFLRHAERQ AERYGVSAAE MLVRAGRRKL
VGGQEDQLVD IALELQREQS TVTA
//
