ID   A0A3M2LQE8_9ACTN        Unreviewed;       346 AA.
AC   A0A3M2LQE8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:RMI39316.1};
DE            EC=3.5.4.4 {ECO:0000313|EMBL:RMI39316.1};
GN   ORFNames=EBO15_30180 {ECO:0000313|EMBL:RMI39316.1};
OS   Actinomadura harenae.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=2483351 {ECO:0000313|EMBL:RMI39316.1, ECO:0000313|Proteomes:UP000282674};
RN   [1] {ECO:0000313|EMBL:RMI39316.1, ECO:0000313|Proteomes:UP000282674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEAU-Ht49 {ECO:0000313|EMBL:RMI39316.1,
RC   ECO:0000313|Proteomes:UP000282674};
RA   Hu J.;
RT   "Isolation from soil.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMI39316.1}.
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DR   EMBL; RFFG01000070; RMI39316.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M2LQE8; -.
DR   OrthoDB; 9779574at2; -.
DR   Proteomes; UP000282674; Unassembled WGS sequence.
DR   GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:RMI39316.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282674}.
FT   DOMAIN          16..339
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   346 AA;  37281 MW;  04A9CBC6F139AFFC CRC64;
     MLTENTPVHA FIDALPKVEL HVHLVGSASV PTVLELANRH PDGSVPTTEA ELDAFYTFRN
     FTDFANVYLA VSDLVRTPED VATLVLGAAR DLSAQNVRYF ELTVTPFSHQ RVGMPMPAIT
     EALNDAARRA QSEHGVRLAY IFDIPAENGA EGALGTVEHA VRYAPDALVG FGIGGGEEFR
     PPNRDAFRDA FARARAAGLR SLPHGGEMTG PETIWECLDH YGAERIGHGI NCLADPRLVE
     VLRERQIPLE VCPTSNVRTG QVPDLASHPL PRLLEEGLFV TLNSDDPPMF DTTLTGEYRV
     AADVFGLGPA ELAGLARNGV TASCLDAVDQ KAILDEIDAV TASHTS
//