ID   A0A3M2LV68_9ACTN        Unreviewed;       759 AA.
AC   A0A3M2LV68;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=MMPL family transporter {ECO:0000313|EMBL:RMI41122.1};
GN   ORFNames=EBN88_11535 {ECO:0000313|EMBL:RMI41122.1};
OS   Streptomyces triticirhizae.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2483353 {ECO:0000313|EMBL:RMI41122.1, ECO:0000313|Proteomes:UP000278673};
RN   [1] {ECO:0000313|EMBL:RMI41122.1, ECO:0000313|Proteomes:UP000278673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEAU-YY642 {ECO:0000313|EMBL:RMI41122.1,
RC   ECO:0000313|Proteomes:UP000278673};
RA   Han C.;
RT   "Isolation, diversity and antifungal activity of actinobacteria from
RT   wheat.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMI41122.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; RFFJ01000049; RMI41122.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M2LV68; -.
DR   Proteomes; UP000278673; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        177..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        229..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        281..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        308..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        375..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        544..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        573..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        603..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        660..680
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        686..705
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          199..331
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          735..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  79952 MW;  22F394FA5892AACD CRC64;
     MLQWLARSTT TRPRLFLLLA LLFVAASVVL GGGVAERLQN GGTTDPNAES TQAAELLDQK
     FTDGRPNLAL LVTVRDGADV DDPAVASEGT RLADQLAQED DVLGVNSYWA TGSPALRSGD
     GQHALIVARI AGTEDEAGDT LERITPDYQG VHGPVEVAFG GATQIRYDVE TQSQDDLLLA
     EIIALPLTLL VLVLVFRSAI AALLPICVAL VTVMGTNAAL RVVTGFTDVS IFALNLTTAL
     GLGLAVDYGL FIVRRYREEL NAGRPTQEAI RITMATAGRT VAFSALTVAV SLSALLTFPM
     YYLRSFAYAG IAVVLIAAAA ALVMLPALMM VLGHRINSAD LTRLFGGRRA AGRDGSATPG
     RRWAAVGRAV IRRPVGFVCA GIAVLVVMAL PVFSVSFGNI DDRQLPDTLE SRQVHDVIRE
     TFDARPTGAL EVLGDGVDAQ AQLSEIDGYA ARVSELEGVA RVESAAGVHQ EGRLVVEPGP
     ANAAFVSQDG SATYLSVIPS VEDVSPESQQ LVRDIRQLDS PFPVLVAGGA AELVDTQDSI
     ADRLPGALAI ILLATTVLLF LMTGSLVVPL KAIVLNFLSL GATFGAVVWV FQEGHLTGVV
     GDFTVTGFVA ATLPVLMFCV AFGLTMDYEV FVLSRIKEEY DRTGDTSEAI VHGLRRSGGV
     VSAAAGVLAI VLVAIGTSQV VNLKMLGLGL ALAVLLDAFL VRGLLMPAVM RLLGRANWWA
     PRPLKSLHAR FGISEEGTPS TPAAAPGPLP ERERTDVAG
//