ID   A0A3M2LY10_9ACTN        Unreviewed;      2567 AA.
AC   A0A3M2LY10;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:RMI42092.1};
GN   ORFNames=EBO15_20795 {ECO:0000313|EMBL:RMI42092.1};
OS   Actinomadura harenae.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=2483351 {ECO:0000313|EMBL:RMI42092.1, ECO:0000313|Proteomes:UP000282674};
RN   [1] {ECO:0000313|EMBL:RMI42092.1, ECO:0000313|Proteomes:UP000282674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEAU-Ht49 {ECO:0000313|EMBL:RMI42092.1,
RC   ECO:0000313|Proteomes:UP000282674};
RA   Hu J.;
RT   "Isolation from soil.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMI42092.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; RFFG01000036; RMI42092.1; -; Genomic_DNA.
DR   OrthoDB; 3671989at2; -.
DR   Proteomes; UP000282674; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd19531; LCL_NRPS-like; 1.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282674}.
FT   DOMAIN          1737..1813
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1020..1052
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1716..1735
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2217..2244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2567 AA;  267757 MW;  A979A97D5651C359 CRC64;
     MNPEPTARDV TERATPADQP TLPAALAKSC EMFADRVAVR DLRAGTDLTY AALSGRVADL
     AAALTQVPAP ATGAGRGRNR LPVPVVAVLM EPGADLAVAA AAVVSAGAAY LPLAPAAPDA
     HLARVLAAAQ PDLVVTGPEQ DHRVPGLPSV SVRDLLTRPI DPRRFASSSD RQAPTARPDA
     PAYVIFTSGS SGTPKGVVVA HAALLNSTRA RSDAYGDPER IPLLHSPGFD VSVGVMWWSL
     LSGATLVVGP PLADIAATWR LLRTERITHL VYAAGLYPTL LAVAAADTTR TTSGNAHAGG
     SCLRQVMIGS EAWGEAVADR HAALLPDASL WNEYGPTEAA VWASSALVYD ASTRHRAPVT
     LGAPISGVSF HVADPEDPGG RLVEDWGTAG RPNSGAAAGE LLISGANLAL GYLRQRDATR
     RAFTTLPTGE RAYRTGDLVR RTEAGWVFAG RVDRQVKIGG VRVEPAAVED VLLTHPDIAA
     AHVSAVRPAR DVPAVLVAYV QPVRPPGPPD PPGAEGAWAE RIRAHCALHL PPGQVPARLM
     VVDALPVTLN GKVDTARLPD PFGSPGLAAQ AGGQTEADHL AAAVAQILCV ATLGEQVPLP
     AAGADSLALV RIAALLASDY RVQVPPSRLA GPTTLAQIRA LLATAPPADT DRPPLVCGAA
     TASGAGTERQ DAPLSGQQLQ LWLLEQAAPD SLAYQTQSSL LLDGVLDVEA LQAALTLLVA
     RHEILRTTLH DGPSGPVQRV HAPWPVDLPV TDLTVRDGRD IESHDLEGHW LEGRAADIVD
     ELTRHRFDVT RLPLIRWHLL RLGPRRWRLV QVEHHLPHDG WSVGVLLTEL MAAYDALVQG
     ASPDLDPVLR GPVPQYRDYA AWYHRWRSTA DHARHGRYWQ TALEGASPIG VTFDGDHERP
     PRQSHRGGLL RGQVDPAVLA RLDELGRAHG VTRFAMFMTA FTALVHAHTR AEDFTVGTAL
     ANRADPAAAR MLGMLVNAVP LRARLHGDPT LGELAARIQQ VVLDLHDHQE LPFTDILAAV
     TGTPGTRPGP DGPGHPGSGS RGRGSTGDGG RDGSRTPWFS LMFAFHDSPR PHLLQAAGVT
     GRVRIEHNGS AKNDINVVCV PSPATEAGDS AAVEVLWEYN RDLYEPGTAQ AHLRDFMACL
     RAVADSWDRR LSTADATGTA ARTAADPHLA DLRTARRKGA AGQRGPRTLP GGVTAAIAAT
     PDEPAVIHAG TTLTFRQLER LACDIEVALE DAGIGIGDRV AVACPPSPLL VAALLAVTRR
     GAAYLCLDLA HPHQRLADLL ALAAPALILA DSSSSGGSGS SGLEGLGVEV LYADRLPTGG
     RARRPVHGAA APAYVVFTSG SGGTPKGVVA SHGNAVTALT ARTAVFGRHL GGARPRTLVT
     LPTVFDVAPS MIFWTLTAGG TVILPDRPGD AADPLLVREL VDRHQVTCLN FVSSYYSQFL
     QALPGPWPAP VRVVAVGGEP CTPDLVTRHT KLLPGAVLCN EYGPTETTVW ATAAILHRPP
     SHPPSGRPSG RRVPIGTPVP GTVVAVLDAD LQPVPQGARG ELCIAGGGVT PGYLDEPDLT
     AERFTVPARG PLAGIRLYRT GDVGRVGPDG RLECLGRMDD QVKIRGHRVD PAEVARCLAA
     HPLVARAHVT AFSGAGGVTE LGAVVAAGQE AAPGDRGRGG GDHDQDGLGD DLRRWVTQRL
     PSPMVPSRLR LVPALPLTAS GKVDRDTVTA LLATAPAPHQ ARPGAPGGRR PADPAAAAMA
     DRLRGLWRAA IPVLAAGGDG SWCGGDFFAA GGDSLTAIRL SSAARTAGLP LSVSDILTHP
     VLADQAALLT LRIAAQPSPG QGAPAGERVA RPGGTPVALT GAQQWFFAQR FADPDHFAQA
     RLFDVQAGTD GVVLAAAVRA ALARHEATRL CFVSGPSGWH AVLAAPAVHP IDALHLPASP
     DGDEGVGAAQ ARLQANLSIT DGRLLAAALL QHGTRGHAPA PATTGAAEGR RTLLLVLHHL
     IVDAVSWDVL ARDIAACYAD LTSAGAAAPL RLAPPLPGPA AAPSGDQAAD EERYWRDLAD
     APKPGLALTT APRCCFGDRR HLQIVLSPTA TRLLTLESAA LHRVGGQEIF LAAVARATAA
     LTRRGTGLYA MLEGHGRSDL DHGGDLLGWF TCLHPVLLGA PQSAGNAATT PPDAHVDADA
     LLREAAAIRA HLAHVPRGGA AFAPARYSPP VSPGDSPAVA VADLELPEVT INYLATASPN
     QPAGPIGAPR PAPNSGIGPA NTPPTSLDLT LGRHRPAADG EDRGPLLRLS CSFDPGRLEC
     RAVEGAVAAI SEMIEDLARC VPLAEPPDQP RAESLFLLPG LGDALAPLAG LANRLSSHRA
     CYGLTRPDVP ADASIEELAA VHAAALTGRQ AGPYHLAGWS FGAAVAFQTA RDLTAAGHTV
     HLTLLDPPHL YDTETERRRQ TLLVTAHHLT RLLPEQDPDL LRRILENTLV TAADTAALDD
     LTAQIAALAS TSENAADAAE QALPRDELLW RVRVLAGSAA ALAAWRPCGV LPTLVIASPT
     GELGGWDQLS GTPPTVVTVP ATDHRALLTS PAVIDLLTDT HPAETGS
//