ID   A0A3M2LZH4_9ACTN        Unreviewed;       718 AA.
AC   A0A3M2LZH4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=MMPL family transporter {ECO:0000313|EMBL:RMI42542.1};
GN   ORFNames=EBO15_19060 {ECO:0000313|EMBL:RMI42542.1};
OS   Actinomadura harenae.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=2483351 {ECO:0000313|EMBL:RMI42542.1, ECO:0000313|Proteomes:UP000282674};
RN   [1] {ECO:0000313|EMBL:RMI42542.1, ECO:0000313|Proteomes:UP000282674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEAU-Ht49 {ECO:0000313|EMBL:RMI42542.1,
RC   ECO:0000313|Proteomes:UP000282674};
RA   Hu J.;
RT   "Isolation from soil.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMI42542.1}.
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DR   EMBL; RFFG01000032; RMI42542.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M2LZH4; -.
DR   Proteomes; UP000282674; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282674};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        225..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        299..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        534..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        560..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        601..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        642..668
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        688..709
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          38..368
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          398..715
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   718 AA;  73991 MW;  3FC64397EA9FC164 CRC64;
     MTRWCFRHHL VVLLLWAVAL GGTVLAGRLA GGAYAKDFKP PASESVRAAD LMRTAFPARS
     GDTDVVVWRV DGPGTVRDAA VRDRMRAVLD RIAALPDVGQ ALSPYRADGA GQTSADGRTA
     YAQITYTRPT GDLAADRIER VVDTARSAAT SGLTVEVGGP AAGGVDQPPP HLAEFAGLAV
     AAVVLYLAFG SFPAMLLPLV TALFGVGLGL AGIELLGHAM TMPSAALLLS TLIGLGVGID
     YALFVVSRYR GGLREGLPPE PAAIDAARTS GRSVLFAGGI VCVSLLGMFA MGLDFLNGVA
     VATSLTVLLS VAAALTLLPA LFGLLGTRVL SRRERRLPPA ASSSGVPTTP RPGRAARWAD
     VVQRRPRTFA VVASALVAVL SLPAFSLRLG VGDQGTLPES NTARRAYDML ADAFGPGFNG
     PLQMVVRPRD GGAEVPPAVL ERLVGDVRAT RGVAKATVMP LPGQARGGMS AGGAAPRMAV
     VQVIPATSPQ DAGTGALIDR LRTGPAARDG SLEVLVGGAT AVDKDLASTL AARLPLFLAV
     IVALGSVLLL AAFRSLAVPL LAAVLNVAAT GTALGITVAL FQWGWGTGVL GIGKPVPVTS
     FLPVLMIAML FGLAMDYQVF LTGRMREEWL RTRDARRAVH AGLVHGGGVI VSAAVIMIAV
     FGAFVMSGDR EGMLVGAGLA GAVAVEAFVL RTMLVPAVMT LLGAAAWWLP ARAARERT
//