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Database: UniProt
Entry: A0A3M2M042_9ACTN
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ID   A0A3M2M042_9ACTN        Unreviewed;       717 AA.
AC   A0A3M2M042;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN   ECO:0000313|EMBL:RMI42937.1};
GN   ORFNames=EBO15_18115 {ECO:0000313|EMBL:RMI42937.1};
OS   Actinomadura harenae.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=2483351 {ECO:0000313|EMBL:RMI42937.1, ECO:0000313|Proteomes:UP000282674};
RN   [1] {ECO:0000313|EMBL:RMI42937.1, ECO:0000313|Proteomes:UP000282674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEAU-Ht49 {ECO:0000313|EMBL:RMI42937.1,
RC   ECO:0000313|Proteomes:UP000282674};
RA   Hu J.;
RT   "Isolation from soil.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000256|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC       Rule:MF_00203}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMI42937.1}.
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DR   EMBL; RFFG01000029; RMI42937.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M2M042; -.
DR   OrthoDB; 9804933at2; -.
DR   Proteomes; UP000282674; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   NCBIfam; TIGR00194; uvrC; 1.
DR   PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR   PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF14520; HHH_5; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR   SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW   Rule:MF_00203}; SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000259|PROSITE:PS50164"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   DOMAIN          259..529
FT                   /note="UvrC family homology region profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50165"
FT   REGION          470..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          653..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..484
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  79560 MW;  ED4B6818FC359876 CRC64;
     MADPATYRPA PGTIPDEPGV YRFRDEHGRV IYVGKAKNLR SRLSSYFADF ATLHPRTQTM
     VSTASRVDWT VVSTEVEALQ LEYSWIKEFD PRFNVKYRDD KSYPYLAVTL NEEFPRVQVM
     RGAKRKGVRY FGPYSHAWAI RETVDQLLRV FPVRTCSAGV FKRQHQLDRP CLLGYIDKCS
     APCVGRVTPE EHRDLAADFC DFMAGNTGRY IKRLERDMRE AATSMEYERA ARLRDDIRAL
     ERALEKQTVV LADDTDLDMI AFAEDELEAA VQVFYIRGGR IRGQRGWVVD KVEAVTTPDL
     VEQFLIQIYG DSDSVPREVY VPALPPDDEA MTELLAEQRG GPVRLRVPQR GDKKALLETV
     QRNALEALKQ HKTRRASDLT TRSVALRELQ EALELDEAPL RVECYDVSNL QGTNVVASMV
     VFEDGLARKS EYRRFTIKAV EGQDDVRSIH EVISRRFRRY LAESEKTGEL DVLGDGHDDD
     GDASGTGAEP AAHGPIDPET GRPRRFAYPP NLVLVDGGPP QVAAAQRALD ELGVDDIAVV
     GIAKRLEELW LPGDDDPVIL PRNSESMFLV QRIRDEAHRF AITFHRQKRS KSMTVSELDG
     VPGLGPARRT ALVKHFGSVK RLKEATPEQI AEVPGIGLRT AETIAAALNG PGASAAARKD
     APGNAPTAAP NDTARPEDTA RPDDGTRTTP DAAGAADGGT DSGTDNRGDA DNRGKRT
//
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