ID A0A3M2M4Z9_9ACTN Unreviewed; 802 AA.
AC A0A3M2M4Z9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=EBO15_14380 {ECO:0000313|EMBL:RMI44100.1};
OS Actinomadura harenae.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=2483351 {ECO:0000313|EMBL:RMI44100.1, ECO:0000313|Proteomes:UP000282674};
RN [1] {ECO:0000313|EMBL:RMI44100.1, ECO:0000313|Proteomes:UP000282674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEAU-Ht49 {ECO:0000313|EMBL:RMI44100.1,
RC ECO:0000313|Proteomes:UP000282674};
RA Hu J.;
RT "Isolation from soil.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMI44100.1}.
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DR EMBL; RFFG01000021; RMI44100.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M2M4Z9; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000282674; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000282674};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 487..784
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 85318 MW; 6CB17244DEFA852F CRC64;
MDSRGESEPI DPAAPEGAAD PFVRVRGARE HNLRNVDVAV PRDALVVFTG VSGSGKSSLA
FGTLYAEAQR RYLESVAPYA RRLLHQVGAP DVDEISGLPP AVALGQRRSN PSSRSSVGTV
TAVSNSLRML LSRAGDYPEG AARLDSDAFS PNTPVGACPN CHGLGEVHDV TEASLVPDAS
LSIREGAVAS WPGGWMGKNL REILEELGVD VDRPWRELPR DRRDWILFTD EQPVVTVHPV
REAHRTQGTY QGTFHSAKRL VLRAYAESKS EKRRQKAETF MTSAICPVCH GKRLRPEALA
VTFAGRDVAD LAALPLIDLA AVLRPHARGT GPAAVLSRDL IERVEVLTEL GLGYLGTDRA
STTLSAGELQ RLRMATQLRS GLFGVVYVLD EPSAGLHPAD TEALMASLQR LRTAGNSLFV
IEHDLSVVHR ADWIVDVGPG AGVHGGEVLY SGPVDALRDV PASVTRRYLF GEAGRPEYAP
REPSGWLKLR GVSRHNLRDL DVDVPMGVFT AITGVSGSGK SSLLDAIADA PTDGEGRVVR
VDQKPIGRTP RSNLATYTGL FDAVRKVFAE TGEARARGYD AGRFSFNVAG GRCENCQGEG
YVSVELLFLP STYAPCPVCG GARYNPETLQ VTYRDVNIAQ VLNMTVDDAA EFLADVRPAA
RSLRTLREVG LGYLRLGQPA TELSGGEAQR VKLASELQRA RHGGTLYVLD EPSTGLHPAD
TEVLVGQLRA LVGEGATVVV VEHDMDVVAT ADHVIDLGPG GGAAGGRVIA QGAPADVAAS
SGRTAPYLRT ALSGGGRAGQ AS
//
