ID   A0A3M2RS09_9HYPO        Unreviewed;       692 AA.
AC   A0A3M2RS09;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=PLD phosphodiesterase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CDV36_012398 {ECO:0000313|EMBL:RMJ08009.1};
OS   Fusarium kuroshium.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium solani species complex.
OX   NCBI_TaxID=2010991 {ECO:0000313|EMBL:RMJ08009.1, ECO:0000313|Proteomes:UP000277212};
RN   [1] {ECO:0000313|EMBL:RMJ08009.1, ECO:0000313|Proteomes:UP000277212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCR3666 {ECO:0000313|EMBL:RMJ08009.1};
RA   Stajich J.E., Carrillo J., Kijimoto T., Eskalen A., O'Donnell K.,
RA   Kasson M.;
RT   "Comparative genomic analysis of Ambrosia Fusariam Clade fungi.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMJ08009.1}.
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DR   EMBL; NKUJ01000310; RMJ08009.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M2RS09; -.
DR   STRING; 2010991.A0A3M2RS09; -.
DR   Proteomes; UP000277212; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd09122; PLDc_Tdp1_1; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR   InterPro; IPR010347; Tdp1.
DR   InterPro; IPR003903; UIM_dom.
DR   PANTHER; PTHR12415; TYROSYL-DNA PHOSPHODIESTERASE 1; 1.
DR   PANTHER; PTHR12415:SF4; TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF06087; Tyr-DNA_phospho; 1.
DR   Pfam; PF02809; UIM; 1.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   PROSITE; PS50330; UIM; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000277212}.
FT   REGION          1..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          477..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..97
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..131
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..517
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..620
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..662
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        227
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT   ACT_SITE        465
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT   BINDING         229
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT   BINDING         467
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT   SITE            538
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610347-3"
SQ   SEQUENCE   692 AA;  75327 MW;  BF61643D118AC0D6 CRC64;
     MSGSRQDVPD PGSDMDEDEA LRYAIALSLQ EQEVKESQDQ QTSSQVPPAS ASSASSSRRN
     GTGSGGASFG LLSLDRKKME QERLQRLAKR RRSPLDEDDD DDVVEVPPPK RKTPVEPSRS
     LPGPWSPSSS PPFPGGVVKR TWARGYPRTS EDIKIEEVFQ KDRLELAVLS SYQWDDEWLL
     SKIDLRRTKL LLVAYAADES QKREMQSNTP PGIRFCFPAM NGPGAMHSKL QLLKYPDYLR
     VVVPTANLVP YDWGETGVME NMVFLIDLPK LEASVHHQPT PFCTELGRFL SETGVGVGMV
     SSLANYDFSR TKHLGFVYTI PGGHVGDSLK RIGYCGLGNS VASLGLATDD PVEVDIVCAS
     LGSLNYDLVG AMYNACRGDD GMAEYKSRIG RTGAAAKNKS SSPWQAKLKD RFRIYFPTDE
     TVAQSRGGRM AAGTICVQPK WWRSATFPTE LVRDCVNNRE GLLMHSKMIF VRRQVSKSTK
     AGAAEQSSAE PRQRRGPGIE PERGQHEPDR HDENDDSAEL NAAVLSPGWA YVGSANLSES
     AWGRIVKDRA TGQPKMSCRN WESGVVVRVS SRNSSSSSGI SSSRGTTTNS SMARASANAG
     STSKNHHQSQ SSSAVLVSLS GGSTEVKAAE AQARVQAGNP SGEPDKGGDT SHTQQQQVTD
     MGIFDGTVPV PVRVPGRRYR AGEEPWFYSG QG
//