ID   A0A3M2SU86_9EURO        Unreviewed;       468 AA.
AC   A0A3M2SU86;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=PHISP_08027 {ECO:0000313|EMBL:RMJ21099.1};
OS   Aspergillus sp. HF37.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1960876 {ECO:0000313|EMBL:RMJ21099.1, ECO:0000313|Proteomes:UP000272442};
RN   [1] {ECO:0000313|EMBL:RMJ21099.1, ECO:0000313|Proteomes:UP000272442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF37 {ECO:0000313|EMBL:RMJ21099.1,
RC   ECO:0000313|Proteomes:UP000272442};
RA   Tafer H., Lopandic K.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMJ21099.1}.
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DR   EMBL; RAQS01000585; RMJ21099.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M2SU86; -.
DR   STRING; 1960876.A0A3M2SU86; -.
DR   Proteomes; UP000272442; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000272442};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..468
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase
FT                   domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018253881"
FT   DOMAIN          72..351
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   468 AA;  51169 MW;  E20C7444D6164909 CRC64;
     MAFLLVALSL LLAAGLYLYH VNRGMVNLPE ETRLLSPHRW SVDQVKATYK RNLDEPIDVT
     KSLPPKQSRR YIVVGGAGLV GNWIVQHLLA RGEDPAAIRV ADLQAPNHKT LDRGVAYIKT
     NVTDESSVSD AFSQKWPMTV VHLPLTVFHT AAVIRPADRL KLFLHLCRNV NVDGTRNVLN
     AAKKAGASCM IATSSGSVSI HRRNFWIAPW TRTPKGLTQI LSDSTPLPKE HEEFFGNYAV
     TKAEAERIVR DADSPDSNFR TGCIRPANGV YGIGDTAATV TGHYMRQGGS PSWMYNILQN
     FVNAENVSIA HLFYEQRLNE QTPISNRPNI GGQAFTVTDP NPAVSYGDVY LLLPTLAKTP
     VKFPAVSPVP LLLLSYLIEW YTSGAAAAIA LLHLAVHTIV DDSRARKAPE DGGLGYRPPF
     STMDGMCKEV IEWNSLVEKK GEGVVQDTAP VSVSSEGVDV NVAAPPKM
//