ID A0A3M2T4W6_9EURO Unreviewed; 819 AA.
AC A0A3M2T4W6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PHISP_04304 {ECO:0000313|EMBL:RMJ24828.1};
OS Aspergillus sp. HF37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1960876 {ECO:0000313|EMBL:RMJ24828.1, ECO:0000313|Proteomes:UP000272442};
RN [1] {ECO:0000313|EMBL:RMJ24828.1, ECO:0000313|Proteomes:UP000272442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HF37 {ECO:0000313|EMBL:RMJ24828.1,
RC ECO:0000313|Proteomes:UP000272442};
RA Tafer H., Lopandic K.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMJ24828.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RAQS01000154; RMJ24828.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M2T4W6; -.
DR STRING; 1960876.A0A3M2T4W6; -.
DR Proteomes; UP000272442; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:RMJ24828.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:RMJ24828.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|EMBL:RMJ24828.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000272442}.
FT DOMAIN 339..501
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 555..709
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 92716 MW; F6B750DDB8BBFF11 CRC64;
MPAKRKATDS GRSSRASKRA TPIPDGVGSS DDYSDYEEDV KDDNLKNVVS KFSLESFTNK
KGGPKQDPDF GYKDFSSLPL KADHVNRPLW IDPLKGIITL ESFSPLAPQA ADFLTTIAEP
MSRPVYLHEY RLTGNSLYAA VSVGLQPGDI INFLDRLSKT PLPDSIKSFI VDFTKSYGKI
KVVLKHNRFF VESTDPAMLQ MLLQDEVIGR QRLQGSEGII QQEAPKLGGL VIPGTKDAAG
VQQASEEKPA ENGQQNERQE NEILLAIRDD DDDEDQAQVH SFEIPNDSVE PVKARCQAMG
CPALEEYDFR NDDVNPTLDI DLKPSARIRS YQEKSLSKMF GNGRAKSGII VLPCGAGKTL
VGITGACTIK KGTIILCTSS MSVVQWRNEF LRWSNIDPGD IAIFTSDNKE KFRRSTGIIV
STYSMVSQTR ARSHDAQKMM DWIQSREWGL MILDEVHVVP ASMFRKVTSA IATQSKLGLT
ATLLREDDKI KDLNFLIGPK LYEANWMELA EQGHIAKVQC AEVWCPMTTE FYSEYLRERS
RKAALLYIMN PRKFQACQYL IDYHERRGDK VIVFSDNVYA LRQYALKLNK AFIYGGTPQN
ERMRILENFQ HNEQVNTIFL SKIGDTSLDL PEATCLIQIS SHYGSRRQEA QRLGRILRAK
RRNDEGFNAF FYSLVSKDTD EMFYSSKRQA FLVDQGYAFK VITHLQGIEN LDRLAYATPA
ERRELLQEVM LQNETSAEVE HVTDDLFSER GNRGKAKKEA VKRSAATLSG LAGGEDMAYV
EYNKSKNKQL KDKAGHHPLF RKLERERQRR KKEMQDMSR
//
