ID   A0A3M2T714_9EURO        Unreviewed;       329 AA.
AC   A0A3M2T714;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=alcohol dehydrogenase {ECO:0000256|ARBA:ARBA00013190};
DE            EC=1.1.1.1 {ECO:0000256|ARBA:ARBA00013190};
GN   ORFNames=PHISP_03663 {ECO:0000313|EMBL:RMJ25471.1};
OS   Aspergillus sp. HF37.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1960876 {ECO:0000313|EMBL:RMJ25471.1, ECO:0000313|Proteomes:UP000272442};
RN   [1] {ECO:0000313|EMBL:RMJ25471.1, ECO:0000313|Proteomes:UP000272442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF37 {ECO:0000313|EMBL:RMJ25471.1,
RC   ECO:0000313|Proteomes:UP000272442};
RA   Tafer H., Lopandic K.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMJ25471.1}.
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DR   EMBL; RAQS01000119; RMJ25471.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M2T714; -.
DR   STRING; 1960876.A0A3M2T714; -.
DR   Proteomes; UP000272442; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42940; ALCOHOL DEHYDROGENASE 1-RELATED; 1.
DR   PANTHER; PTHR42940:SF7; ALCOHOL DEHYDROGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000272442};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          16..328
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   329 AA;  34798 MW;  645AB008ED97B67C CRC64;
     MTLPKTFKQA VFKSAGAPLA IEEATLTPPG PGEILVKVEA CGVCFSDMFA QNNILGGGFP
     IVPGHEFVGR VVAVGDNVAG WAVGDRIGGA WHGGHDGTCK PCRKGWYQMC DNRAVNGETK
     GGGYAEYCLV NSEAAVRVPA HVSAAKYAPI LCAGVSVFNS IRHMKVSPGE TVAVQGLGGL
     GHIAIQYANR MGYRVVAISR DGEKEQLVRD LGAHEYVDCS RADAGEVLTK LGGAALVVST
     APSAEVMTPL LKGLGVLGKL LILSVPGQVS VDTTVMLRYG LSVQVWPCGH SNDTEEAINF
     TELQKINCMV EEFPLERANE AFGEFHSVR
//