ID A0A3M2T943_9EURO Unreviewed; 3281 AA.
AC A0A3M2T943;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Nonribosomal peptide synthase {ECO:0000313|EMBL:RMJ26305.1};
GN ORFNames=PHISP_02837 {ECO:0000313|EMBL:RMJ26305.1};
OS Aspergillus sp. HF37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1960876 {ECO:0000313|EMBL:RMJ26305.1, ECO:0000313|Proteomes:UP000272442};
RN [1] {ECO:0000313|EMBL:RMJ26305.1, ECO:0000313|Proteomes:UP000272442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HF37 {ECO:0000313|EMBL:RMJ26305.1,
RC ECO:0000313|Proteomes:UP000272442};
RA Tafer H., Lopandic K.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMJ26305.1}.
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DR EMBL; RAQS01000083; RMJ26305.1; -; Genomic_DNA.
DR STRING; 1960876.A0A3M2T943; -.
DR Proteomes; UP000272442; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 3.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000272442}.
FT DOMAIN 603..679
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1672..1748
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2760..2836
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3281 AA; 360318 MW; 4CCA3D0FF8E0DDB2 CRC64;
MAPHLEDAER IPPVEKTKDS GSVSGISDDI PNAKEIPVGS GETGKVVQQL RQLNAEVSKP
VESCAHWLIS ERCRAQPEAL AVCAWDGDLT YGQLDSLADS LAASLSNKGV RTETFVPICS
EKSRWVPVAM LAVLKAGGAF ALLDPSHPLK RLVGVCQTLN AKVVVSSRER SSMASQLAPT
ASVVVVDDGI LQVARAAVPA SHVGPGNAAW AIFTSGSTEG IPKGIVIEHR SFCSAAVAHS
AALDLTSSSR VLQFASYAFD ACLLETLSVL VVGGCVCIPS EIDRRRDLVG SFRRFGVNWA
FLTPSTARII DAAELWTLST LVLGGEALSH EDILKWAPHV QLFNGYGPAE CTIFATASRC
QGPGAHHANI GYGMGASCWV VDEDDPEKLK PVGSVGEILI SGPTVSRGYI GDERRTADAF
VAYPGWLSSI VQPDQNGRVH RTGDLGRFLE DGSIQFVGRK DTQAKIHGQR LESSEVEYHL
RKYFPDVSGV AVEVVTPANK GDACLVAFLA YSIGLSNQNA SFSKAEDLLT APSDDFRSRI
HAAKTQFNQI MPTYMVPTAF LQISSIPLTT SGKTDRRLLR QVASSMTRQQ LQQYCEAAAE
KRPPSSKMEA TIQQLWAEVL QLPLQDIGVD DSFWSLGGSS IHAMKLAGIA RRSELDVGVA
DVWDHQSLEE MAAAIQSRAK CVTEEAVVPF SLIQPPDDRT GLVQLALKQC HVQEGDVEDI
YPCTPLQEGL VSLAAKRPSA YTISREYQLP ISIDVERFRV AWDATIDANP ILRTRIVQAG
SGAMYQVVVR ESALWNVRNP GQEVPKDWLG WKLGQRLIRL ALSNQTCAEE RVYFTLVLHH
ALTDGWAIQY LLKQAQAAYM EMSLPSTPFS PFVKQLLHTK EDTTSFWQSQ FKGLNAVTFP
KLPSPDYIVN PTAKTTCTLG TDAAVIDGVT APSRIKLSWA VLASLYTESY DVVFGTTVTG
RGAPVLGVEE MTGPTIASFP MRFLLNPDES VADALHNVQK HSNDTIPFEQ AGLQRISRMG
PEAAAACQFQ SLLVVQPDHE FHPSIFSDMR DISEPFAFSS YAITLNCKLS RGTMELEATY
DPQVVSEIQM RRILNQLKHI FKQIERLPTL SLRDLELASP EDLERLRAWN GSLPEPLEQC
VHEAIQRRCL EQPDAIAVCS WNGTFSYGDL DSHSTMLATR LAHLGVGPEV FVPLCFEKSR
WTIVAMLGVL KAGGAFILLD PSQPVQRLQN ICQNVQPSFV LASEANAGRA TDLAPQVVVL
GDSNKTWMAC PSSSEILKAA PDNAMYAAFT SGSTSGQPKG IVISNKAFAS CAAANGAAMH
LSNTSRVLQF GSYAFDICMA EIFTTLLCGG CICVPSDSER LQNLPQAVAR MQANWSFFTS
SFARALNPVD FPTLTTIIVG GEIVTRKEIT MWQNRDLLIA YGPVECSVIC VLGRASSAAD
AGRRIGSGIR CRTWVVDSDN HERLAPIGAV GELLLEGPNV GRGYLNDPRK TASAFIKSPS
WLQRIQGKNR FPVYKTGDLV RYTDDGSLYY IRRKDTQVKV RGQRVELSEI EHDIQKFFEH
SIDAVAEPVT IRNESDRQIL AAFIHTERRS DVAHQSLLTG MSAPFRSQVQ GLESYLSEKL
PSYMVPDLFL PLAHLPLTLN GKVDRERLRR EVESRSQGIS REYASSLGTN VQPSSEIERK
LQAIWASVLN MTPDSIGIQD NFFRLGGDSI SAMHVAAQCA TDGMVVTIAD IFRQKTISQL
GQSIQTSKPV PSAEAASIPR TGRQIQPLSL VDRKLDREKL LQQAAGICQI PINHIEDIYP
CTPLQEGLMA LSAKKSGQFI GKLEGELPAD INLHAFRSAW VATVAANPIL RTRMAQLGDL
GTCQVVVHDL PPWQEFDDIV SYAGHIKGAD MELGMPLIDF SILRPGSSAK TYKFHMTLHH
AIYDGWSLHL IWKHVRAAYY NTPLTPQPFN HFIEYIGNVR GAEKFWRSEF NGLDAPVFPS
VPSSKYVPTA TSSLHHPISK GGGRNSEFTM STIIQLAWSI IMSIYTDSED VVFGLTLNGR
SAPVARIDEM TGPTFATIPL RVRVDPRSTV RESLSFVQNK TTAMIPFQQF GLQNISQLSV
EAAQACSFQC HLGIQPPSTT KGNDLFAFEQ GEHQDYRAFA NYAFVLVCHL DGGDENNIMV
TANYDENIVH TTDAKRMVHQ FEHVLRQISH DYDLPLNKLS LVSLDDRLQL SEWNQHLPPS
YDKCLHDLVL AHCARDPTSP AIAAWDGAVS YGELDIMSLQ LAKQLQELGV QKGSMVPLCF
NKSKWVIITM IAVLRAGGAC VSLDPAHPRE RIRNILRLTS SRLVLTSPEN QGIATGAGSA
VATIPFNHQQ VPSGWSVPEV TPQDPAFIVF TSGSTSGVPK GIDMQHSALC TSIRDHSSDM
NLDNRSRALH FASYAFDASI YEIFSTLGNG GCVCVPSEYD RMHNLAGFIR EHQVNFAIFT
PSVINTLLCP VDVPHLQTIV LGGEAVTPET VHTWAPTNVT LINGYGPAET TICAVGNIPA
HGWVTGTIGP MTGSVGWITT PSDPSRLAPI GAVGELLIEG PVVTRGYLND PERTAAAYIP
APSWHADFRN IQEGHRLYRT GDLVQYTKNG WIKFAGRKDT QVKLRGQRIE LGEVEHHARQ
CFPCAGELIA EVVVRAEGSG VPVLAVFVYG NTEGTEFNSS EEQGLFVSPD DKFLSQVRAT
TTKLKGVVPA YMVPGVFLRL SRVPRTPSGK IDRLQLRDQA AVHLGGTQKS PNTRDVVNQE
PKNEQEQLLR GLWAAVLKIP TEGISADDDF FHLGGDSVRA MKLASMGRRQ GLDLSVSLVF
DYPVLSSLTQ AAGRLLQNGE TDKYQPGSLA GVGDLESFIS NFPGQSWPFD PRDVVDILPT
TELQHMLLKG KVVTYIQLAF PMRVSPDRLE AACRAIVRQH PTLRTVFVPY EGGYLQVVLR
DINFRLLRLN CEDNLEKFTE SVCRRDSSSP VRFGTPHFQP YLLSQSDSHH MFVMRTTHAQ
YDNASLPLVI RDMSNAYNEE DLDLAGPPFA KYLQYRQAPK SPETYQFWND YIEGSQMTEL
KPANLARPAC CADEHEHLVR FFGEMPLPSP PEGITMGSLA KAAWAVVLAR RTGERDVVFG
HIINGRDAPI ADVANISGPC ITMSPFRVTI QPSWATADDL LRHVQSQYRR AMPFANLDFK
HMLKRTSVWP VETDFGSVLT HQDGETQMAF PFDGVECSWM PRDFGVPSHF HIVTLPRGDK
LAIVLSASCR KISPGAAEEL VDEMCEAITD LSRGSLDMLR I
//
