ID A0A3M2TA36_9EURO Unreviewed; 646 AA.
AC A0A3M2TA36;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=VHS domain protein {ECO:0000313|EMBL:RMJ26644.1};
GN ORFNames=PHISP_02456 {ECO:0000313|EMBL:RMJ26644.1};
OS Aspergillus sp. HF37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1960876 {ECO:0000313|EMBL:RMJ26644.1, ECO:0000313|Proteomes:UP000272442};
RN [1] {ECO:0000313|EMBL:RMJ26644.1, ECO:0000313|Proteomes:UP000272442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HF37 {ECO:0000313|EMBL:RMJ26644.1,
RC ECO:0000313|Proteomes:UP000272442};
RA Tafer H., Lopandic K.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
CC {ECO:0000256|ARBA:ARBA00011446}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMJ26644.1}.
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DR EMBL; RAQS01000070; RMJ26644.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M2TA36; -.
DR STRING; 1960876.A0A3M2TA36; -.
DR Proteomes; UP000272442; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0016482; P:cytosolic transport; IEA:UniProt.
DR GO; GO:0016197; P:endosomal transport; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd14235; GAT_GGA_fungi; 1.
DR CDD; cd16998; VHS_GGA_fungi; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR47180; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED; 1.
DR PANTHER; PTHR47180:SF1; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000272442};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 25..161
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 188..315
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 524..644
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 314..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..456
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 70273 MW; F179ACDEF9BF68D0 CRC64;
MAARDRFGAF AVLGLSPLQR AIRNACDLQN YEPNLALNLE VADLINTKKG NAPREAAFEI
VHLVNSRNQN VALLALALLD ICVKNCGYPF QLQISTKEFL NELVRRFPER PPMRPSRVQH
RILEAIEEWR QTICQTSRYK EDLGFIRDMH RLLLYKGYMF PEVRHEDAAV LNPSDNLRSA
EEMEEEEREA QSAKLQELIR RGTPADLQEA NRLMKVMAGF DNRHKTDYRA KAAEEVAKVQ
QKAKILEEML QSHQPGEGIA EGDVFEELAN ALQSAHPKIQ KMCEEESDDP EAVNKLLEIN
DSIHRTMERY KLVKRGEHDA ASRIPKGTLG TTTGVSKNAN NELSLIDFDP EPSPSSNGNA
AQAAPPQGSS LESDLLGLSM DEEPAPLVGG ISLGPGDTMT NPAAASSTPP LQQGPGPSAP
KPNYDILSLN SSQPIPPTST PSPALSQQPT ATPPPADPFA SLVSGSSRKA SPLPAGQPPA
PAPASSSLLD LAGSNAPAGR ATATTSKAAE DDEWNFTSSL PQSSALPTTN RLQVLNSSLR
IEFVARRNAS AGQQIQVVAL FTNTTSQPLN ELHFQVAVEK AYTLQLRPQT GREMRAQQQN
GVQQEMVVEG VEAGKGNSVK MRFKVSYQVG GEAREEQGMV PALGIS
//
