ID   A0A3M2TE15_9EURO        Unreviewed;       525 AA.
AC   A0A3M2TE15;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN   ORFNames=PHISP_01079 {ECO:0000313|EMBL:RMJ28051.1};
OS   Aspergillus sp. HF37.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1960876 {ECO:0000313|EMBL:RMJ28051.1, ECO:0000313|Proteomes:UP000272442};
RN   [1] {ECO:0000313|EMBL:RMJ28051.1, ECO:0000313|Proteomes:UP000272442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF37 {ECO:0000313|EMBL:RMJ28051.1,
RC   ECO:0000313|Proteomes:UP000272442};
RA   Tafer H., Lopandic K.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMJ28051.1}.
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DR   EMBL; RAQS01000027; RMJ28051.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M2TE15; -.
DR   STRING; 1960876.A0A3M2TE15; -.
DR   Proteomes; UP000272442; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR   CDD; cd07229; Pat_TGL3_like; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF44; TRIACYLGLYCEROL LIPASE 3; 1.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000272442}.
FT   DOMAIN          170..390
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   525 AA;  59370 MW;  62D8FFD3B4B69699 CRC64;
     MVLDVALFWK KKLLSWWMSK SPRDQLLHRL AAAQNYDEWE QTAFELDELL SADLWRQTPT
     SRHYDYRLIL GRLEALMSAR EDEDILTLGS LLRSGLVRNL GNITSPKLFI HAYAGTKLLI
     DDYITQVALS IQHVTELQTV PTRDSGFTSQ AKLELLHDTR QAFGRTTLLL QGGSTFGLCL
     CHLGVVKALH LQGLLPRIIT GTATGALIAA LVGIHTEDEL LAFLNGDGID LTTFDRHRGA
     RVPFGDRKPP SREAGNSWLQ RILRRIKWFV HQEYFLDADV LEECVRANVG DLTFEEAYAR
     SKRALNITVA STPSRSGTPN LLNYLTAPNV LIWSAAVASN SSLTPNSPVI IYCKDETGSV
     VPWPHSQDAI SRSWRHEGDR ESPLPRIAEL FNVNHFIVSQ TRPYLIPFLR SELNPGQWNI
     TRPLMRLVVV EIRHRLRQLD YIGLLPHFLG RILIDETIPG PNLILVPDLS LKDFGKIFQG
     PGKEVLKTWI LKGERGVWPA VSALKVRCAI EIELDKGYQI VRRRR
//