ID A0A3M6QFA7_9BURK Unreviewed; 915 AA.
AC A0A3M6QFA7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:RMX01786.1};
GN ORFNames=EBQ25_03175 {ECO:0000313|EMBL:RMX01786.1};
OS Allofranklinella schreckenbergeri.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Allofranklinella.
OX NCBI_TaxID=1076744 {ECO:0000313|EMBL:RMX01786.1, ECO:0000313|Proteomes:UP000267035};
RN [1] {ECO:0000313|EMBL:RMX01786.1, ECO:0000313|Proteomes:UP000267035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML161473 {ECO:0000313|EMBL:RMX01786.1,
RC ECO:0000313|Proteomes:UP000267035};
RA Bernier A.-M., Bernard K.;
RT "Comamonadaceae CDC group NO-1 genome sequencing and assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMX01786.1}.
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DR EMBL; RDQL01000003; RMX01786.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M6QFA7; -.
DR Proteomes; UP000267035; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000267035}.
FT DOMAIN 725..741
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 858..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 651..658
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 915 AA; 98044 MW; 8EE8D8C99ACB20B3 CRC64;
MMAQYLTLKA QHPDTLLFYR MGDFYEMFYD DAHKAARLLN ITLTQRGQSA GQPVPMAGVP
FHSVDTYLAR LIKLGESVAI CEQIGDPATS KGPVERKVVR IVTPGTLTDA ALLPDKQEAV
LLAIHEAQGR QAKGQARYGL AWLSITQGMV HLAQCSAGAL HGWLDRIGAS ETLYSAGAST
QGAHSLDALL AQRQLSGQGS AAQALPAWQF DAALGVRKLT GHLQVASLHA WDAADLPLAH
AAAAALLHYT AHTQGRDLQH LQGIEVERDD ATLHLPATTR RNLELVQTLR GESSPTLFSL
LDTCATSMGS RQLKQWLLNP PRDRRIAAQR LERIGALRAG AALPLWQHYR GALQGAADVE
RISARIALEQ VRPRELVALK NTLRQALALA NGRQSAEVAE TTGALETTGA LETAGTDHSA
FCLDSLLAAL AAPEGLIDLL QAAIVQEPAA LVRDGGVIAQ GFDAELDELR ALQDSADTFL
LALEARERER TGIANLRVQY NKVHGFYIEV SQGQLHRVPV DYKRRQTLKN AERFITPELK
TFEDKALSAQ ERALAREKHL YQQLLEQLQA HIPALYRIAG ALAQLDALCA LAERSATLGW
CAPQFAIEPC IDIVQGRHPV VEMRLAQTAQ TSFIANDTAL GGKRRMQIIT GPNMGGKSTY
MRQVALIALL ASMGSYVPAQ SCRIGPIDAI HTRIGAADDL ANAQSTFMLE MTEAAQILHS
ATAHSLVLMD EIGRGTSTYD GLALAGSIAT YLHDKTQAFT LFATHYFELT ELPAKLAHAI
NTHVAAAETG SHIVFLHELQ PGPASRSYGI HVARLAGMPA GVIQHARATL EHLQSQGTQA
QGDLFSAALD DGLVATGPGD GAPAWGADGA AGEEGASAQA PSAVEQALAA LDIDALSPRQ
AQAQLYALKD LLGAT
//
