ID A0A3M6VQN6_9STRA Unreviewed; 729 AA.
AC A0A3M6VQN6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=DD237_006361 {ECO:0000313|EMBL:RQM14501.1}, DD238_005457
GN {ECO:0000313|EMBL:RMX69034.1};
OS Peronospora effusa.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Peronospora.
OX NCBI_TaxID=542832 {ECO:0000313|EMBL:RMX69034.1, ECO:0000313|Proteomes:UP000282087};
RN [1] {ECO:0000313|Proteomes:UP000282087, ECO:0000313|Proteomes:UP000286097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R13 {ECO:0000313|EMBL:RQM14501.1,
RC ECO:0000313|Proteomes:UP000286097}, and R14
RC {ECO:0000313|EMBL:RMX69034.1, ECO:0000313|Proteomes:UP000282087};
RA Fletcher K., Klosterman S.J., Derevnina L., Martin F., Koike S.,
RA Reyes Chin-Wo S., Mou B., Michelmore R.;
RT "Comparative genomics of downy mildews reveals potential adaptations to
RT biotrophy.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMX69034.1}.
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DR EMBL; QLLG01000040; RMX69034.1; -; Genomic_DNA.
DR EMBL; QKXF01000200; RQM14501.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M6VQN6; -.
DR STRING; 542832.A0A3M6VQN6; -.
DR VEuPathDB; FungiDB:DD237_006361; -.
DR Proteomes; UP000282087; Unassembled WGS sequence.
DR Proteomes; UP000286097; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000282087};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..729
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033799815"
FT TRANSMEM 696..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..193
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 729 AA; 78469 MW; 62B7A7F876C91549 CRC64;
MRLPIFSSLL PVALLLLELR NLEASSVTAG KPEQLITSGG ECVRLFHSKG SIGCRSMSNS
DMALLYPIVT LNDLQNFIND RSKSLKDKTK NVLVMPESLL DYDVISLGFD RIGGLFIFPD
ANTKGSNISF ESSTPQGDGT VDARLNPFSN DKIKWNPMGT GLLTKLLPFP VVMLQNATIG
AEFTKRAQIN MKKTTGASYK AFMNYYFGPE EMDSIKCLKF VNIHGDRSPK CDPIGGQSAW
AMRGNLKSKE IVMAMAGMDT TSLSHVLASG ANTGASGLVA LLAAAHALKG LPDSVFTKKV
VFAAFQAEKF GFVGSRKFLS DLQQFTKDPK GACAFPVHNS VSPMGSTFCT SPMLSSTEFA
NLKLANIAYA IAVDQVGILP ESGNFTVHVN PHANDASNLI DAILNAPSAA SGITKGSTGS
LPPTPLTSFV NDAEYGQRDL VGAVLAGYAD SYTSKKTYNS RHDEFALLNI DAVVQAAQVL
AESVFTLASS KATKQQLDKI KVDTWLVESM LLCITTDWSC DLMKNYSQYM KATLIEYLSL
PDTASPSYAV PATLYAGSMD VDGSMMLLKK SDDSILSLLN DSWSDDTYSV RLFPNAYEFF
TRAFLASAMV PNATADAAAT CSQSQGCRDG GKGMECVYPG VCATKSAFHH EAISPGLTRT
TTALQYDIVN SSMPIWTEPQ WDTDIGSYSF PDPGVWIGWI TLAIGLAVTG LGTGASFMVL
RSVHKMKLM
//