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Database: UniProt
Entry: A0A3M6VQN6_9STRA
LinkDB: A0A3M6VQN6_9STRA
Original site: A0A3M6VQN6_9STRA 
ID   A0A3M6VQN6_9STRA        Unreviewed;       729 AA.
AC   A0A3M6VQN6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN   ORFNames=DD237_006361 {ECO:0000313|EMBL:RQM14501.1}, DD238_005457
GN   {ECO:0000313|EMBL:RMX69034.1};
OS   Peronospora effusa.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Peronospora.
OX   NCBI_TaxID=542832 {ECO:0000313|EMBL:RMX69034.1, ECO:0000313|Proteomes:UP000282087};
RN   [1] {ECO:0000313|Proteomes:UP000282087, ECO:0000313|Proteomes:UP000286097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R13 {ECO:0000313|EMBL:RQM14501.1,
RC   ECO:0000313|Proteomes:UP000286097}, and R14
RC   {ECO:0000313|EMBL:RMX69034.1, ECO:0000313|Proteomes:UP000282087};
RA   Fletcher K., Klosterman S.J., Derevnina L., Martin F., Koike S.,
RA   Reyes Chin-Wo S., Mou B., Michelmore R.;
RT   "Comparative genomics of downy mildews reveals potential adaptations to
RT   biotrophy.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMX69034.1}.
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DR   EMBL; QLLG01000040; RMX69034.1; -; Genomic_DNA.
DR   EMBL; QKXF01000200; RQM14501.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M6VQN6; -.
DR   STRING; 542832.A0A3M6VQN6; -.
DR   VEuPathDB; FungiDB:DD237_006361; -.
DR   Proteomes; UP000282087; Unassembled WGS sequence.
DR   Proteomes; UP000286097; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282087};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..729
FT                   /note="Nicastrin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5033799815"
FT   TRANSMEM        696..720
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          42..193
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   729 AA;  78469 MW;  62B7A7F876C91549 CRC64;
     MRLPIFSSLL PVALLLLELR NLEASSVTAG KPEQLITSGG ECVRLFHSKG SIGCRSMSNS
     DMALLYPIVT LNDLQNFIND RSKSLKDKTK NVLVMPESLL DYDVISLGFD RIGGLFIFPD
     ANTKGSNISF ESSTPQGDGT VDARLNPFSN DKIKWNPMGT GLLTKLLPFP VVMLQNATIG
     AEFTKRAQIN MKKTTGASYK AFMNYYFGPE EMDSIKCLKF VNIHGDRSPK CDPIGGQSAW
     AMRGNLKSKE IVMAMAGMDT TSLSHVLASG ANTGASGLVA LLAAAHALKG LPDSVFTKKV
     VFAAFQAEKF GFVGSRKFLS DLQQFTKDPK GACAFPVHNS VSPMGSTFCT SPMLSSTEFA
     NLKLANIAYA IAVDQVGILP ESGNFTVHVN PHANDASNLI DAILNAPSAA SGITKGSTGS
     LPPTPLTSFV NDAEYGQRDL VGAVLAGYAD SYTSKKTYNS RHDEFALLNI DAVVQAAQVL
     AESVFTLASS KATKQQLDKI KVDTWLVESM LLCITTDWSC DLMKNYSQYM KATLIEYLSL
     PDTASPSYAV PATLYAGSMD VDGSMMLLKK SDDSILSLLN DSWSDDTYSV RLFPNAYEFF
     TRAFLASAMV PNATADAAAT CSQSQGCRDG GKGMECVYPG VCATKSAFHH EAISPGLTRT
     TTALQYDIVN SSMPIWTEPQ WDTDIGSYSF PDPGVWIGWI TLAIGLAVTG LGTGASFMVL
     RSVHKMKLM
//
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