ID A0A3M6VSE7_9STRA Unreviewed; 4602 AA.
AC A0A3M6VSE7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=DD238_001342 {ECO:0000313|EMBL:RMX69387.1};
OS Peronospora effusa.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Peronospora.
OX NCBI_TaxID=542832 {ECO:0000313|EMBL:RMX69387.1, ECO:0000313|Proteomes:UP000282087};
RN [1] {ECO:0000313|EMBL:RMX69387.1, ECO:0000313|Proteomes:UP000282087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R14 {ECO:0000313|EMBL:RMX69387.1,
RC ECO:0000313|Proteomes:UP000282087};
RA Fletcher K., Klosterman S.J., Derevnina L., Martin F., Koike S.,
RA Reyes Chin-Wo S., Mou B., Michelmore R.;
RT "Comparative genomics of downy mildews reveals potential adaptations to
RT biotrophy.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMX69387.1}.
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DR EMBL; QLLG01000027; RMX69387.1; -; Genomic_DNA.
DR STRING; 542832.A0A3M6VSE7; -.
DR VEuPathDB; FungiDB:DD237_000331; -.
DR Proteomes; UP000282087; Unassembled WGS sequence.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 2.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000282087}.
FT DOMAIN 3375..3912
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 4214..4544
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4570..4602
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2798..2848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2990..3039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4520..4540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2798..2812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2819..2847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3023..3039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4602 AA; 513390 MW; 417B42216D0AB1C2 CRC64;
MNVDVVRQKL LEGDTDVVLK ELTDLYRRAE ILHTPQLGRI LEALFPVWKG LLQNKLPPQL
HASMQNRCRK MLLQILNRLP SNETLRPYVT QLLQLLMEVL QKDNEDNALI ALKTLFDLHR
NYRPGLRNEV QPFLELVQLM YKNLQTTMKK QFSGPPETFK SSFVSTATTP TAAKAASSPA
IVSETAKELT VAGKEMLSAT SGATIESKPA DTTVQHVTDG GNTGETTTVA TISTGAPESI
AVSATAAADR EARTGEPVCS NLESFKTISE LPLIIMLLFQ CYPSYIESYI PVLVPLMMSA
LALRAPETLT TTHPSRYLDF LDCQVKTLSF VTYLLRGCAK LMRPFQDAIC ENTVKLLIAC
PKDAFVLRKD IFVAARHIIS TDFRRGFYPQ LELLMDDDVL VGKGRCSFYQ IRPLAYSTLA
DMIHHVRDML TLEQVSTIVN FYGKRIHDST LPISIQTTSI RLLLNLVDIS AKNEDADAWK
GRNILSRILL IISGKFGTTL ANLPAALATT QRSKSSGDRC DLLEGGAMDK IKQSSLLPRD
VVQKTQYERK LEALLLPHMR VQRPADSSLE EEPSIRDVKS LLRTMTLGIR AVIWCTANYR
NPHAKDLSTV DANTTDGSSL VTPSTSQGIH AGLNAHSFDV VGSSPGRVSG SNHVYPLTDD
ERLLIAKVLR NGLRCFILYT LSENTLSEEK QMLDHFAGAF TVLEAADFRD LFISNIQLLY
ECILQDHAIL TIPQHFLANS NVSCWFAEIL LKFLITQMED LSVEAEGDLP DTKRLEKIMT
IDNLEFEKMR RVPQVHRASI VLRLFKIVFG SVTLFKSNES ALFPHLRTII ESCLKQATFT
KHPDNYLLLL RALFRSISGG KYENFYKEVF PLLPGVLSAL MRLQKHMGKP AMQEVLLELC
LTIPARLSSL LQYLPSLMKS VVRAITSRGE LAYLGLRTLE FWVDNLNPDF LYPIMTSQDR
LLTEIIEALN THLIPPPYSY GELAMRILGK IGGRNRQYLM DPLNLDYHEH SFTGLTFMFQ
WGEERDNTDF DMKGDGVALS QNGKFQMKMD VLVTQATTIL RTYLRKSSAE LDNSCKTDSR
LADVDEFEEG ENPTSPSILL EKDDKTLELE TETMEKIRKS ILQHKRCAFV FVSRAAVVSL
NVNDYANADQ ESDEHEIDAD DLSAQHVEPM RKVISQEALQ ATRKQLLLVL FETMVDIDVG
MEAKKLLQGI AGHLTVLALS KCSREQPDFA VLSSLRASTL YAATRGLSPG RHLATTKRIE
TLRQATYGTA KMVEADVTND FFSFVQVVTL ALSSPDQHAV DTAKEIVTFS IKTAIAQFDS
PRSAVELGGA LFNSMCEVFA HACYDKGSWR QKLGGAIGIQ LLVDLLEPQW CHENELTIIK
AFFFVLSDHP PEVSVTVSAE IGEALVKIVK TAWRARLGYV DQLGDNDQKK KDFLSCIAFQ
DTEVFQMFVV EFLSAKAPTR RFAKRCIATV ALLQETSASA LLYPYNQLIS KQITGCNLRM
LPSNTRTGFV DAMAYALSLD PPIFSLTKEI MMFLQEVWKL ISEDSQRDGV TMIGAESPGK
VGGMAPAIPG SGVSAQEYPF GLSQACELRI AAARLLRAAF LAAPNDLNQH PEYRNRFVGV
FFRYLTGQPP ELVQVAQDAL LDVIQLNKQN KDVFLPKELL QQCLRPVLLN LADYRKLNLP
LLEGLSRLLT LLSSCFNVTL GEKLLEHLKQ WRDPDRIIKA GIWKSGEEPA VAAAIVDLFH
LLPLNDAFLK ALINCVVDLE AVLPKYGSYG KMSSPYRIPL TRFLNRYASM TVSFFLKREH
LVEVKYSSLF QQLIKLPEAA PLRAVIIGDG GIESVIEATF NAALKLNASG FGDTKTGADV
LGDAKVQTQV QLNAQKAATQ AAVTAQAQGM TVSAAEARGE QARAAYVVKA QSQMNAQQAL
KVQSQVQIQA NAQKLHAQTL AAAQAQGLSL VQAQAKAQFA SKDYIAKAQS HISSVAVQTS
LPSPAISPLV TQQQAKQLQA QIQVNAQKVH AQALATAQAQ GLKPTQAQEK AKQAQATYVH
RANAQAQAKI ARAQSQDLAS SMVLGSSSTA VIGGPFASKT QQEALELHYQ GLRLIRSICK
LHPSWLASQM LIIDCLRKLW RSPARVQRLM AHDRLPIKFH LESKWLIKCL IIYSRVKQDD
VQVLLDMLSV FLHRTPFDFG FLQTFYREEV ATKYSTANKR NLVRLFLRML RDTGASEEVK
VHAVQLLIMP VLTTSFEDPS INNIDVMDLD TVMWMLREIL ASKDYPPDAM QSLRIELLKL
GTLLIQHMSK YVTDHRKEVI KFAWNHLKAH DLTSKLWAYV NVCRFISVYD TPPKIVLQVY
VALLRTHEMD ARFLVRKAFD ILLPALPSRL PSNEFIKAIK WTKKIAYEEG HVLGQLVHIW
FLIVRHPALF YPFRGQFVPL MVNSLNRLAI PPSSTPDNRR LAVNIADLVI SWEQTRQARL
AMRGGPKGTS IGGELKRGSP AMGATTVETL DAHVVKKRKI LTTEGSCASS TNTLVVQTSE
DSSGRGTGSL QIQVPTQALI TGIGPQQGQV LASPSLEANR VASNEDDFEL SGAMVDLVIN
FAFRFALASA DKQETSRLAK TCGELFDKAL RLWPSASIRF SYFDKLIAVT AETVIRQQQQ
LQASVNAVAT DSGGTGQQVS APASLPPTVM PPFFDVPKGA PLSSPAILDA VLGILNSLVT
PEVVTMSKRP IQYVIQYAPR IMKLLEPCFD RQNHEIQASL TKFLRRMTEL YPPSCAPQPL
VACKFYPWLR EIINERIVNA AMYQQDLNAG RTGLPGGSNL LASKTKGKNV AQSVTGPKPK
KGGLSSNATV GHSHAAGKQQ QKDPSDINPL INHEAARMRL LFSQHPRALV SPSSYPGEFT
LKLLSGLAET TPDFVDHFAA ALLKLAQRFT REHLIQSASE GSGGAYGGKH GGNNGTAIGV
ESGQAVVDSF GRNRVMATPS LAIVNEWNQM QTGRSNLAVN NIVRHVVKKR EVSGEKSASK
KKGSANDQFL GSEMAKTKAG STMKKKMGTS ASSTSARSGF VDGGSKRPIG LLVLCYALLA
KCSFPSSEHR RLYTNLLVHC LEGSFNIPLL LQITRIVAKM VASTDTHHQI LTTKDKMTLL
SKMATFDRLN EISAIPLNEE YYRLVIKLCE HPPSELKTQA PVLHLSPTPQ SHSLTSHFIA
GLLAPDPATR EKFLKIFFTA TGPGPVARLQ LVLRQDWQAC GTRYWPVIAI ETLMAALSPT
ASPSVSAVRS PAFRTTTTSA KTSAKTSTHS EFLNSYGQVK SSELISSLCD LAHIDLELAK
ELWVNLFSAV WELLKESDQV QMASQLLKIL ASKYNKRDLN VPLGASTPRR TNVVQTLMKG
IVSTRSSAPV MTPELVLHIA SAYDVWSYAL RLCEFHVEKS NQSVETRLRW IEALSTIYKQ
LGEDDLRVGL SFENVAQPET RTALTLEALG CVHEAQEEYF RALSRAQSGR ASIEDVNLFE
LRLWEERWVG CARQLCQWQL MNDFAKSTQN QELLLDCAWK RGDWSSAKQL LLSPSMQSST
ELGCPQTRLQ RLYISILDAD KHSAIDTLAA QTAELALHQW QGLPRILSRA HLPLMHLFHK
FVEVKESIQM MEDIKSASTQ HAALPNLKPS INTWRERLPN KWEPILLWDD ILTWRSHMFQ
VVKTTFSWSD AQVLACMHDS PWSVIKLAHT ARKQRLPDVC LGALAKLYSV PAMDVQDAFS
KLREQVSICY ESATEYSGGL SILNTTNLDY FSIRQKAEMF RLKALFSEAQ GSLSEANQTF
SHCLQICDSY GKGWLSWGHY CYRLFLLRKE LALASQTIAC YLQAIHHRCN SARLMIARVL
WLLNMDDRHG VLIQAFETHG KQLPIWIWII WIPQLLMALG RPEAPQIRGL LRGLSAKFPQ
ALYYTMRAFF LENRDNALML ANQHQPSVAA SSMGVSPSAS ATSLSGGACM YYRTKSGHVV
GIPATMSVAQ VQEVPGLVGP PRPTPAAFNA TPGVVLSLDA WAERVRSNGS DGQSLKAEVG
PVQYTEDLLN FLRRSHDSLT FEMECMLEEM ITRFRPEPEE ELLTAVHALL LKCYQLPRLT
KTEPVPKMLR AALARVCRKL FVLLPHQKNE NHEAFVEEFK DAFERDFTPL GNDDAPQQDK
SATTLYEIMN RLKRWKSLLQ LRVKKAGKRN AGKLYLERCS RHLIELSSSN MEVPGQYVSD
SEPIKDLHAR IQHFESTVDV LLRNGFTQRR VTMGGSDGRA YYFLVQYAMT HITRTDERMM
QMYLLLNRLL LRHKETKKRN TIFHVPIVIP LTPRVRLLED NRDFVTLGEI YELDCQIENK
DPDIPWELYR DRVSEAFAAA GTENDTSVQE ERRVAQAKAR AFHEICSEHV PETLLAKYVH
GISAHSDAYF QFRSEFIKHL ALSSFLSYVL FVGDRAPHRV LFSRRTGRVV STELRPGYAS
SGILEEATTM PFRLTRNLYS FMTRSGVQGP FSLGMTAAAE AFMSEEDILS NQLCLFFRDD
LLSWHASKTR LLSFDSQAVG RASSPSASPR PVSPALTQRR VESQVQQRVE ANVSLVLERI
RGVSLKKASG ESSRGRSVQE LLDIATSPER QREMYPTWSP WL
//