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Database: UniProt
Entry: A0A3M7BHD8_HORWE
LinkDB: A0A3M7BHD8_HORWE
Original site: A0A3M7BHD8_HORWE 
ID   A0A3M7BHD8_HORWE        Unreviewed;       406 AA.
AC   A0A3M7BHD8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   22-FEB-2023, entry version 12.
DE   RecName: Full=Prephenate dehydrogenase [NADP(+)] {ECO:0000256|PIRNR:PIRNR036510};
DE            Short=PRDH {ECO:0000256|PIRNR:PIRNR036510};
DE            EC=1.3.1.13 {ECO:0000256|PIRNR:PIRNR036510};
GN   ORFNames=D0866_02098 {ECO:0000313|EMBL:RMY39201.1};
OS   Hortaea werneckii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Hortaea.
OX   NCBI_TaxID=91943 {ECO:0000313|EMBL:RMY39201.1, ECO:0000313|Proteomes:UP000276864};
RN   [1] {ECO:0000313|EMBL:RMY39201.1, ECO:0000313|Proteomes:UP000276864}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EXF-6651 {ECO:0000313|EMBL:RMY39201.1,
RC   ECO:0000313|Proteomes:UP000276864};
RX   PubMed=29764372; DOI=10.1186/s12864-018-4751-5;
RA   Gostincar C., Stajich J.E., Zupancic J., Zalar P., Gunde-Cimerman N.;
RT   "Genomic evidence for intraspecific hybridization in a clonal and extremely
RT   halotolerant yeast.";
RL   BMC Genomics 19:364-364(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC         NADPH; Xref=Rhea:RHEA:21640, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC         ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.13;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036510};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC       hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR036510}.
CC   -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036510}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RMY39201.1}.
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DR   EMBL; QWIM01000131; RMY39201.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M7BHD8; -.
DR   VEuPathDB; FungiDB:BTJ68_01724; -.
DR   UniPathway; UPA00122; UER00962.
DR   Proteomes; UP000276864; Unassembled WGS sequence.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR003099; Prephen_DH.
DR   InterPro; IPR012385; Prephenate_DH_fun.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   PIRSF; PIRSF036510; PDH_fung; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW   NADP {ECO:0000256|PIRNR:PIRNR036510};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR036510};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276864};
KW   Tyrosine biosynthesis {ECO:0000256|PIRNR:PIRNR036510}.
FT   DOMAIN          1..258
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   406 AA;  46009 MW;  A01B01619151BE68 CRC64;
     MLAVAPLSRQ EAVTAAVVTD TSNISILPNG HFVSRSSDWI MYSVEARNID AVVASYGPST
     KMGAIVGGQT STKAPEIEAF ERHLPSDVEI VSCHSLHGPG VNPKGQPLVI IPHRAKQSSV
     QLVERILGCL ESKFVPLSAE KHDRITADTQ AVTHAAFLSM GTAWQANNQF PWEIPRYLGG
     IENVKINLTL RIYSNKWHVY AGLAILNPSA RAQIRQYAES VTELYKLMLG GDRKELRDRI
     YAARAAVFGK REGDEREELL LEDELLDRFS LGDKPAQRVR NNHLSLLSIV DCWWKLGIVP
     YDHMICSTPL FRLWLGITEY VYRNEELLEE CIETAIEDQS FRADDLEFCF AARDWSERVS
     LGHMDAYREK FEKIQKYFEP RFPEATKLGN EMIRTIEENL NSRKQA
//
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