ID A0A3M7P2E3_BRAPC Unreviewed; 359 AA.
AC A0A3M7P2E3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial {ECO:0000256|ARBA:ARBA00016714};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
DE AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase {ECO:0000256|ARBA:ARBA00031181};
GN ORFNames=BpHYR1_053089 {ECO:0000313|EMBL:RMZ93246.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RMZ93246.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RMZ93246.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RMZ93246.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline
CC catabolite. Has high activity toward isobutyryl-CoA. Could be an
CC isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also
CC hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000256|ARBA:ARBA00024871}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMZ93246.1}.
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DR EMBL; REGN01013966; RMZ93246.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M7P2E3; -.
DR STRING; 10195.A0A3M7P2E3; -.
DR UniPathway; UPA00362; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:RMZ93246.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133}.
FT DOMAIN 18..342
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 359 AA; 40524 MW; C697003B13F30BFC CRC64;
MTSSVSNEVL FNRINQVALI TLNRPKQLNS LNLSMAKQMY AYLEDVENDD SIKAVVVKGA
GESAFCAGGD VKSIRELCIQ GQQDKAMEFF RQEYKLDFKI ANFSKPYVAL INGVTMGGGV
GLSVHGRFRV ATEKTLFAMP ETAIGFIPDV GGSYFLPRLE GNIGLYLALT GNRLKGEDVK
RTGIATHFIR MSNLNNLEQK IFESNNLSYE NIDEILEEVC EKVPGEYDSK KISQIFQLNK
TIEEMISELE ADDSEWSRQQ LKLLSKMSPT SLKITLKQLQ LGKNMNLKEA FELEHQLCLR
FTSFNSDFLE GVRCVLVDKG DKPKWNPSSI KEIDEKTVNW YFDPLPNDRN INLLSSSKL
//
