ID A0A3M7P7Q8_BRAPC Unreviewed; 330 AA.
AC A0A3M7P7Q8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Cathepsin L1 {ECO:0000313|EMBL:RMZ94820.1};
GN ORFNames=BpHYR1_019990 {ECO:0000313|EMBL:RMZ94820.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RMZ94820.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RMZ94820.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RMZ94820.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMZ94820.1}.
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DR EMBL; REGN01012787; RMZ94820.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M7P7Q8; -.
DR STRING; 10195.A0A3M7P7Q8; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF917; CATHEPSIN L.1; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..330
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018770084"
FT DOMAIN 25..85
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 113..329
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 330 AA; 36336 MW; 6549498DDB91BEBF CRC64;
MKGLILVFAF VCAASALDSS LNAYWQSFKT VHQKNYASSS EELYRRQIWE NNLQFIRKHN
QEAQLGQHTF TVAMNKFGDL TGQEFGNLYN GFNMTSVMNR RAARQFVAKN VAVPDAVDWR
TQGYVTPVKD QGQCGSCWAF SAIASLEGQH FKQSGSLVSL SEQNLVDCSR KYGNMGCNGG
LMDQAFEYIK ANNGIDTEDS YPYTARDGKC KFDPSAVGAT DTGYVDIPQG DEKALTEAIA
NIGPISVAID ASRSSFQFYS KGIYSDRGCS STRLDHGVTA VGYDSLGQGK DYYIVKNSWG
TSWGDKGYIW LARNDKNMCG IATAASYPLV
//