ID A0A3M7PA39_BRAPC Unreviewed; 334 AA.
AC A0A3M7PA39;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Amiloride-sensitive sodium channel subunit alpha-like isoform X2 {ECO:0000313|EMBL:RMZ95640.1};
GN ORFNames=BpHYR1_002887 {ECO:0000313|EMBL:RMZ95640.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RMZ95640.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RMZ95640.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RMZ95640.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMZ95640.1}.
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DR EMBL; REGN01012356; RMZ95640.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M7PA39; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF295; DEGENERIN LIKE; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679, ECO:0000313|EMBL:RMZ95640.1};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 292..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 334 AA; 38597 MW; B1FDD3A825F4E22B CRC64;
MFISCLYNLR PCNQSQWTWF YNSQCGNCFR FNSDQNSQEI QKTYQAGKYN GLMIELYVGI
PEEQNTLSQT SGAHVYIDDN SIQPLFGQGV DIAPGFGTNL VLQRIKRKQM PQPYSSCIEN
LDTIDSFDSE YYRKVFRSNL TYRQEDCFFA FIQSEIYKNC KCDEIGSNII PENNNPCDNF
EEQNCVLAEF QRLTQSSYKN DIESLCPLEC ESITYGITKS TSRYPSVSYG NDLLKTKQIK
ALFRNRTNIS IEELRENILS LNIYYEYLKQ TEITENRSIS WDGLVGSIGG TLGLFLGISF
LSFVEIIDLL LQIVFLKCKK TTTKVFFIKK ELKN
//
