ID A0A3M7PC08_BRAPC Unreviewed; 456 AA.
AC A0A3M7PC08;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Adam 17-like protease {ECO:0000313|EMBL:RMZ96592.1};
DE Flags: Fragment;
GN ORFNames=BpHYR1_043920 {ECO:0000313|EMBL:RMZ96592.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RMZ96592.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RMZ96592.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RMZ96592.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMZ96592.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; REGN01012040; RMZ96592.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M7PC08; -.
DR STRING; 10195.A0A3M7PC08; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR PANTHER; PTHR45702; ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER; 1.
DR PANTHER; PTHR45702:SF6; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17; 1.
DR Pfam; PF13688; Reprolysin_5; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:RMZ96592.1};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Protease {ECO:0000313|EMBL:RMZ96592.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..456
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017959045"
FT DOMAIN 239..456
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT ACT_SITE 415
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 414
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 418
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 424
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT NON_TER 456
FT /evidence="ECO:0000313|EMBL:RMZ96592.1"
SQ SEQUENCE 456 AA; 52228 MW; D625DDF98CF8677F CRC64;
MKFPTSILLI LIHLDSAIHK QCLAEYVYDD SELPLKSYEK LDYENFEFKS DTSRSKRDTQ
VLDNFYIAPN RLKFRAFNRN FNLILRRDEA IVGDNLSIEL RYSNKPSEFL KDSFSSNYFR
GIVENESYSE VIVYFEEATQ SNSSGQPLIF AHIRIINGTN ENNFYIEPFQ SSGLANSKFK
YLVYRTEDID SNILSNGVFN TTVCHPKYAK ANSQSKRNNI FSRVKSRTKR QNRSKKLKNR
CHLALVADHK FYKEIGNSND KLITAYMVMN IIVAVNNIFT GTKWIFDEGK PNSNYGFSID
KIIIHKEPTI NVYNHYNNKN SSKNADTILN LFGKEDWSNY CLAHLFTYQN FENSVLGLAY
VSSPLPYSIG GICSEPSFFR EKSSSVNTGL SSYKSISSKQ GRLLQKEAEL VTAHELGHNW
GSEHDPSKPD CMPSPSEGGN YLMYSFSNSG NDKNNM
//