ID A0A3M7PQI0_BRAPC Unreviewed; 840 AA.
AC A0A3M7PQI0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 22-FEB-2023, entry version 14.
DE RecName: Full=Vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|ARBA:ARBA00017947, ECO:0000256|PIRNR:PIRNR007949};
GN ORFNames=BpHYR1_010517 {ECO:0000313|EMBL:RNA01005.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RNA01005.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RNA01005.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RNA01005.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport and
CC autophagic pathways. Believed to act as a core component of the
CC putative HOPS and CORVET endosomal tethering complexes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|PIRNR:PIRNR007949}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR007949}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Note=Cytoplasmic, peripheral membrane
CC protein associated with late endosomes/lysosomes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNA01005.1}.
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DR EMBL; REGN01009509; RNA01005.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M7PQI0; -.
DR STRING; 10195.A0A3M7PQI0; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0033263; C:CORVET complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|PIRNR:PIRNR007949};
KW Lysosome {ECO:0000256|PIRNR:PIRNR007949};
KW Membrane {ECO:0000256|PIRNR:PIRNR007949};
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 4..413
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 511..832
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
SQ SEQUENCE 840 AA; 96318 MW; EB028507E564FAA0 CRC64;
MSHTENWIYV DQTTEIFRKN DFYDLKWNID NSVVRAASFA GPIALTRDLN KPDIRPLISI
YSQSGYAIKT FQLEEKAMII GIGWTSSEDL MIIFENGEIQ IRTIYGQLKN VFNVIKDSRA
VDFRIFNTPN TYTGSFTTGC VILSAKNKLV LIKDVYDPKI QQFPDVPGTG ELDSWCVIST
DKNCSILASR QNEIFQIVYG GVPQLLKINF GVEYNSIKKI CVSFGHDYIA LNTDTGYLIV
CNSEMNRIIH KYKSDSTETA LDIAWVSNKA VLALWDNLYL IPLGSDDIKN HFEIYYSSPC
FLIQELDGVR ILTSSSNMLL QVVPKPLRDI FEIASFDASS ALFESSIAFY ENKNQKAEEY
IRSIKEKGSL EDAIANCIQA APHEFDPKYQ AEILRAALFG RYFDDYANAA SYVKMCQIIR
VLNAIRHSQI GLPLTYLEYE ALSPSVVINR LITRRHFALA IEICKYLNMT DEEGIIKILS
NWALYKVSQT DVEDNQIAAM IKSKLGDTPG ISYAEIARRA ISAGRSGLAI RLLDYEVKAS
EQVPLYIEID MPELAIKKAM ESGDTDLIYM VLFWYQSKFN NVSDFMKDIS KKYSIAFNLM
LQYFRQKSQD EESFNEFNDI LNQENLITEQ VCSIVKVALK QQRDDQKMQM FDEARRLYAS
KEVFNTNILN DEIKLIKIQM NLEKNYGKKF NGKSLFETIG ELIRLKFLDE AEKMRKEFKI
SDSSEAWWHL KAKNLAKGSC WDELEKFSKS KKSPIGYEPF VNYCMDANNV QEAKKYFPKV
TPDSRFNCLI KMKCLADALD LAYQKKDIQQ VNIVIGKCDP STQKIIIDKA KMYRAELINK
//