ID A0A3M7PRV1_BRAPC Unreviewed; 660 AA.
AC A0A3M7PRV1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Choline O-acetyltransferase {ECO:0000256|ARBA:ARBA00040495};
DE EC=2.3.1.6 {ECO:0000256|ARBA:ARBA00039091};
GN ORFNames=BpHYR1_038599 {ECO:0000313|EMBL:RNA01378.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RNA01378.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RNA01378.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RNA01378.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNA01378.1}.
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DR EMBL; REGN01009352; RNA01378.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M7PRV1; -.
DR STRING; 10195.A0A3M7PRV1; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF14; CHOLINE O-ACETYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Neurotransmitter biosynthesis {ECO:0000256|ARBA:ARBA00022979};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT DOMAIN 49..645
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 373
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 660 AA; 76881 MW; 7E33885E5452E030 CRC64;
MNSVVTRRSM ILEANKSHCL LKYIETLLKK QREDPDYAKW DVTKPLPKLP VPDLKHTLEK
YLRCLMPILS EEAYDRTEKI VGDFIADGGI GEKLQQVLIK ESEIKENWVY DWWLEDMYLF
NKLPLPINSN PGMIFPKENF NDEDDQLKFA ARLISGIMDY KFVIDQKKIP VDRCSWREKG
QPLCMEQYYR LFSSYRVPGI DKDKLVISNT NLLAEPEHVI VISRNQMFVL DVIVNFTRLS
EDQLYHQLKR IKRLSEEDEN TFSDVGFLTS LPRDEWAKAR LELLRDSTNR DCIDMIERCI
FIVCLDKKVN HNSNKENIMS NDTSELSTLQ MRDYAFQMLH GCSSEDNSGN RWFDKTMQFV
ISEDGVCGLN YEHSTAEGIV VIQLSEHLFR YIEEKRKQKF YRMPSICELP VPRKLRWLIS
EPISVQIQEA KYSFDGRIDD LDLYVIKFEK FGRDFPKKIK TSPDSFIQVS LQFAYYRMYC
RLVSTYESAS TRRFRHGRVD NIRANSCEAL AWIKSMQPDS ALSNKEKYEL FRKAVQYQTD
LMIDNILGNG MDCHLLALKK IAVENGYGTP NLFTDKSFEM SNHFSLSTSQ IPTTMDGSFM
CYGPVVHDGY GCAYNPKPNY ILFAISSFNS CSMTSSSLFA ESLEKCLVEI YDLCSEFLNQ
//
