ID A0A3M7RRI4_BRAPC Unreviewed; 432 AA.
AC A0A3M7RRI4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Sorting nexin {ECO:0000256|PIRNR:PIRNR036924};
GN ORFNames=BpHYR1_025248 {ECO:0000313|EMBL:RNA26176.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RNA26176.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RNA26176.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RNA26176.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- FUNCTION: Involved in several stages of intracellular trafficking.
CC {ECO:0000256|PIRNR:PIRNR036924}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883, ECO:0000256|PIRNR:PIRNR036924}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNA26176.1}.
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DR EMBL; REGN01002783; RNA26176.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M7RRI4; -.
DR STRING; 10195.A0A3M7RRI4; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014637; SNX5/SNX6/SNX32.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR45850:SF1; SORTING NEXIN 6, ISOFORM B; 1.
DR PANTHER; PTHR45850; SORTING NEXIN FAMILY MEMBER; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF036924; Snx5_Snx6; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|PIRNR:PIRNR036924};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036924}.
FT TRANSMEM 397..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..180
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT COILED 317..351
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 432 AA; 50057 MW; 46290321166F3F10 CRC64;
MTLKITNPTA TMDDVFQDTK TERSETVDLN GATSSDELLK IEISDALNEK DKVKFTVKTK
TSMKNFSSSE FSTIREHEEF IWLHDRFVEH EDYAGYIIPP APPRPDFDSS REKLQRLTEG
ENSMTKEEYA KMKQELESEY LALFKKTVQM HEVFLNRLSS HPIFKGDSNL KVFLEYSKNL
NVRSKNTKER FGGFVKSISK NADELRFLNI KETDEFFDGQ KKFLTDYHNK IREECSRADR
MTYVHKSVAD CYIRVSTGLS NVATAELDPL SKFLTKLADY FEAARKTENR VSSDTDLKLS
DTLRYYVRDS KAALDLLHRR TRRLADFETE NRNLEKARKS HKDEKSAEQA QQNAKLKFEQ
ISDLARSELG DFKARRIGMF RKSLSEFVEF QIKHSNVTFF FFLVVLLLKC GQLLLLRCTI
KTIVSASLGN TA
//
