ID   A0A3M7RZK7_BRAPC        Unreviewed;       444 AA.
AC   A0A3M7RZK7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Acid-sensing ion channel 5 {ECO:0000313|EMBL:RNA28850.1};
GN   ORFNames=BpHYR1_024341 {ECO:0000313|EMBL:RNA28850.1};
OS   Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC   Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC   Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX   NCBI_TaxID=10195 {ECO:0000313|EMBL:RNA28850.1, ECO:0000313|Proteomes:UP000276133};
RN   [1] {ECO:0000313|EMBL:RNA28850.1, ECO:0000313|Proteomes:UP000276133}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HYR1 {ECO:0000313|EMBL:RNA28850.1};
RX   PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA   Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA   Gomez A.;
RT   "Genomic signatures of local adaptation to the degree of environmental
RT   predictability in rotifers.";
RL   Sci. Rep. 8:16051-16051(2018).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RNA28850.1}.
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DR   EMBL; REGN01002327; RNA28850.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M7RZK7; -.
DR   Proteomes; UP000276133; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF295; DEGENERIN LIKE; 1.
DR   Pfam; PF00858; ASC; 2.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        34..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   444 AA;  50745 MW;  F1A0BF13F2F3120D CRC64;
     MGKNLVKIFR EWTESISIHG FGNIFRTEFL TIRIIWTIAL LASTGICLFI ITLNVTNFLE
     NEVITKIRVH QKNSLVFPSV TVCNLNPFAT KNELDIVSYF LEKNALDNLT DSAKIRQLRG
     LNSSDLFSNL NMVRYLTAVS YKFLTINGTK INYTEIYDRM FITCLFGAEP CQRSDWSWFF
     DPYYGNCFTF NGKKVNEYHK SNQHGQFFGL IIELNVAIPN DARTLSISSG AHVYINHNPI
     VPLFGEGLDL STGTYSNIAL ERTITKQMPD PYSECKNNLD SIDSFDSEYY RKVFKSNLTY
     RQTDCFNAYI QSQILINCFC NDLHYNLAIE GNNVCDTIED QICISKLYQQ FLNTNYQNEI
     KKFCPLECET VSFNIKKSES KYPSESYGYS FKSVSWDGLV GSVGGTLGLF LGMSALSFVE
     FIDLFFQLIL NSNQSKVKGI STEK
//