ID A0A3M7S9S1_BRAPC Unreviewed; 1300 AA.
AC A0A3M7S9S1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Histone-lysine N-methyltransferase eggless isoform X4 {ECO:0000313|EMBL:RNA32532.1};
DE EC=2.1.1.43 {ECO:0000313|EMBL:RNA32532.1};
GN ORFNames=BpHYR1_024964 {ECO:0000313|EMBL:RNA32532.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RNA32532.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RNA32532.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RNA32532.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNA32532.1}.
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DR EMBL; REGN01001785; RNA32532.1; -; Genomic_DNA.
DR STRING; 10195.A0A3M7S9S1; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10517; SET_SETDB1; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000313|EMBL:RNA32532.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RNA32532.1}.
FT DOMAIN 822..904
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 956..1022
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1025..1275
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1284..1300
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 442..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1300 AA; 150649 MW; B33A78A2205DD127 CRC64;
MLEEINQTLN KNMSVKSSLF EEKSKGLIEE LYKTLEEYFE DALKTVQNQV SLLIREPINE
SLQMSHSIKN LCPERLSLLA SEIAQINRQK LDVKIKSKME SLKKVAGDLA KNSNCEFRLD
EIVNFDLFYS KVEDLMKKFD DILPNVYADL KQNLAIRVTK KSHRLKETDF FSDTEVLEQS
RKISKKKIKR LLANLKNSHL ASNSDRSSFS DDDESNKKNF KQLFYSYSDS LLYQDNLEMD
VGCFNDNDHS LSSDTSSVSS NYCLDQEPFN SLSNSFSSCS INDDYDRDLF RNFQINSDSD
EELASLEAQN LNQDEDCIII CENQNDYQTK ARKSKKLNKC LQIIEKFVST NKELKVPRQQ
ISLGMRCLAL KDRNRFKWKL ARITRITDNN LLSHQVTSSE NNSSQIYKMI CNCKYTVKFD
SDEEDASEPQ DSMDDNINKE LEPTMSEKGD NESDAAEQVV DNSTSDDEII ECTANENNNV
KKRKLKCNTS ELKCCSERRY VKKRTNPSSM GLVELDAKSV AFLDNYEFIP NIYSNKMQNR
ALFEPKSRVV TLYQMKIITC DKSKVLFESE YMSSGTVLEV PSIANFRRYL VLFDNGVALY
VKPDHLFPIF DMFGQPLDLL NLDHLMFLQN YCRIYPERKL VRLNADDLVQ VFFNNRWCTS
KVVDVEGSLV SLLVKSTFFN RKKLSQPLVY SIKLHRGSFC LFPMYEQFIS FLENSIKNCC
ELSPFEEYIK DKRNDTVQNM SSKKYISYFA SSIFPNVGLK SKVSKQKYLE ITNQKSSNEK
VIQGQLKHLN MENMMRDEII PFVPHPCTNA CVAKWENRFT DVKGVNPLLI PVLHGWQRHI
GNISKNPTTM TKKFIRYVTP CGRMLRSTAE IDHYLYLTNS KLTIDMFTTD NYIHTDREFE
ANAKNLKIND IANGQENVAI SVVNCVDSNK PDDFVYSAKR IPLDGVPLNT DPTLMEGCNC
IDNCRDRTKC ACWRKSFEAT LFNSDQMNTN IGYRGRRLLE IVHTGNNCKC DCRCSNRVVQ
NGISVRLQLF KTNSKGWGLR CLDDIPKGTF ICNYSGHLIT EELSDIRGRE LGDEYFAELD
FVEYLKRSQN GIVKNIEEFS SKNSDLDESN LKIMQKKANS RFKEYQRPKQ QQNANKKNSS
FEETFYILLD SDEDEQDRSN PNTFPISKKE DEYNKNRVLN RQQKEKKMVS SIYSNRFFTN
HNNKFFFENY MLDSSVFIMD AKILGNIGRY FNHSCAPNIF VQNVFVDTYD LRFPWIAFFA
NHAIKAGTEL CWDYNYTIGS VQDRILFCHC NASNCRGRLL
//
