ID A0A3M7SL26_BRAPC Unreviewed; 528 AA.
AC A0A3M7SL26;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Acid-sensing ion channel 2 isoform X1 {ECO:0000313|EMBL:RNA36501.1};
GN ORFNames=BpHYR1_010455 {ECO:0000313|EMBL:RNA36501.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RNA36501.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RNA36501.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RNA36501.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNA36501.1}.
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DR EMBL; REGN01001176; RNA36501.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M7SL26; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF295; DEGENERIN LIKE; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 20..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 528 AA; 61260 MW; 877E36B5890EE37D CRC64;
MRLSSFSFRF NLYFCGSDSI SLFFGYIYAF FWLSFLAIPL VITFRVKNQL FFVMKKKILP
GEINELKRQK LCFKDIFLEW TASVSFHGFP KIFLTKYTTI RIIVINYLKY EVVTTIKVIE
KDSLPFPAVT VCNANPFVSE EGLKYVSSFL EENNLTHIYD SELNNFGEKN DQEIFSNNTF
NRFMVTTLSK GLKTEKKKIF SLGLKEILIS CMFNLQQCSE NDWEWYYDYF YGNCHRFNTG
KNLKGEKIDI KYTNNAGKYN GLMVELFTGI PNNHKTLSLT NGAHVFIDDN SFKPITQGGY
DVATGFSTNL AIERIKTKLM PQPYSECIQN LDSIDSFDSE YYRKVFRSNL LYRQSDCFEA
FQLSEIYKNC SCDEMGNNLV YENNNTCDTF TEQLCAITIT QKLLETNFKQ KNKLFCPLEC
ESIRYKVIKS ENNYPSESYG NDLSKTSKIR SLFENRSNIS NEELRKNVLA VSVYYEYSEQ
TEISQSASIS WEGLVGIIGG TLGLFLGMSF LSFVEFFDLF LQIIFKKS
//
