ID A0A3M7T408_BRAPC Unreviewed; 928 AA.
AC A0A3M7T408;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=CSC1 2 isoform X2 {ECO:0000313|EMBL:RNA42649.1};
GN ORFNames=BpHYR1_026220 {ECO:0000313|EMBL:RNA42649.1};
OS Brachionus plicatilis (Marine rotifer) (Brachionus muelleri).
OC Eukaryota; Metazoa; Spiralia; Gnathifera; Rotifera; Eurotatoria;
OC Monogononta; Pseudotrocha; Ploima; Brachionidae; Brachionus.
OX NCBI_TaxID=10195 {ECO:0000313|EMBL:RNA42649.1, ECO:0000313|Proteomes:UP000276133};
RN [1] {ECO:0000313|EMBL:RNA42649.1, ECO:0000313|Proteomes:UP000276133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYR1 {ECO:0000313|EMBL:RNA42649.1};
RX PubMed=30375419; DOI=10.1038/s41598-018-34188-y;
RA Franch-Gras L., Hahn C., Garcia-Roger E.M., Carmona M.J., Serra M.,
RA Gomez A.;
RT "Genomic signatures of local adaptation to the degree of environmental
RT predictability in rotifers.";
RL Sci. Rep. 8:16051-16051(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNA42649.1}.
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DR EMBL; REGN01000333; RNA42649.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M7T408; -.
DR STRING; 10195.A0A3M7T408; -.
DR Proteomes; UP000276133; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF153; RE44586P; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000276133};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 38..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..222
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 239..447
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 458..719
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 795..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 337..364
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 795..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 928 AA; 107028 MW; 5D69F133E0CFF841 CRC64;
MPNSTSMTDL IDQNCRNIYN SNNTGIFIKD YEGIPENLLV NVCAWLAILV LYTFLRRIGD
YGRFGLLKND EERWSVNFFS KFSDTTPATN SAETNAERAG NDVNLVRSDS TISQDFTHNN
EYKEKNILSW ILNVFRLKDK HINEKCGKDA IYYLFFQRYL ITYLFIVTIL SISVLLPINL
QGNLFSSKVF GATTIVNVPP NSQLLWIHLI LSWVFYALGI IFVKIFAKRM EYTESEYVSR
TVLVTNYPSR YAKKEFITKH FEEAYPELVI TDVQFAYNVN KLYKLDNRKH SMLIGKMTSE
KILEQTGERP MMHPFHFGSF VELCCCCCTK CCCKQENNRL TDSIEFYTKK VNELEEKISK
EREKCLKKPL GISFITFKDQ AMADKFLKHY RYGLIGNMIY AYCPTEKCSK CFLCQDLVRP
SSLSHRLNSE FWSAKYAPAP TNIKWENLSK IGIMWWFRCI LINLILIILM IFFTTPSILI
AKAGSWAPVF NVEEIAKILP SYLGEFLPSL LLRLLAALLP VLVSRTALAE MHWTRSGENR
SMMVKTFTLL LFMVLVLPTL GLTSINAIFE WLNNKKEEDN IKWKCVSENG AFFLKYVTTC
SLIGTALDLI RLPELFLYVV RMFYSRSSAE RLAVRMKAAF EFDYGVQYAW ILTVFTVTLC
FSVVCPLITP FGLVYLILKH MVDRYNIYFA YVTTKVDKSI HKSAVKFALS SFIMLQFCIL
FFISLRKKDN ESTSSMTVLQ IIIIVVSCII FFGSFFFGVF KRFTPFNYEK SAQSCGSSPE
DISNDESYCY ITENSSDSGN DTQNVAIEQP SPRKSDGQGF KKTVSKAKKM ILHSPFIPAI
IRSSIQDPYS KLDTKNSRRK SVDSTINEEN IDLEVRNSEA QEEDRLDYGT LTKNKFNENF
LFQQENGSND EQIIPDESRT YSNEGYIE
//
